Acta Neuropathologica

, Volume 51, Issue 3, pp 223–227 | Cite as

Peripheral neuropathy in the spontaneously diabetic BB-Wistar-rat

An ultrastructural study
  • Anders A. F. Sima
Original Works


Peripheral nerves of the diabetic insulin-dependent BB-Wistar-rat were studied ultrastructurally. Conspicuous early changes consisted of mitochondrial accumulation of glycogen in the axons and the development of honey-combed Schwann cell-axon networks. The later stages of the diabetic syndrome showed axonal dwindling and disintegration in both myelinated and unmyelinated fibers. The present findings are compared with those of other experimental diabetic models.

Key words

BB-Wistar-rat Diabetic neuropathy Axonal degeneration 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Anders A. F. Sima
    • 1
  1. 1.Division of Neuropathology, Department of PathologyUniversity of Toronto and Toronto General HospitalTorontoCanada

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