Acta Neuropathologica

, Volume 77, Issue 4, pp 412–419 | Cite as

Role of endoneural cells in experimental allergic neuritis and characterisation of a resident phagocytic cell

  • A. Stevens
  • M. Schabet
  • K. Schott
  • H. Wiethölter
Regular Papers


Electrophysiological, clinical and histological techniques were used to monitor the time course of events related to experimental allergic neuritis (EAN) in 48 Lewis rats. The primary lesion was found to be paranodal demyelination without cellular infiltration. Endoneural phagocytes derive from hematogenous ED1+ED2 monocytes and possibly from resident ED1 ED2+ monocytic cells, not from Schwann cells and fibroblasts. We demonstrate a population of monocytic Ia-bearing, ED1ED2+ spindle-shaped cells residing in normal peripheral nerve and provide evidence for their transformation into macrophages in the course of EAN.

Key words

Experimental allergic neuritis Monocytes Immunohistochemistry Electrophysiology Resident dendritic cell 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • A. Stevens
    • 1
  • M. Schabet
    • 1
  • K. Schott
    • 1
  • H. Wiethölter
    • 1
  1. 1.Abteilung für NeurologieUniversität TübingenTübingenGermany

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