Acta Neuropathologica

, Volume 72, Issue 4, pp 341–348 | Cite as

Pacinian corpuscles in rats with carbon disulphide neuropathy

  • I. Jirmanová
Original Works

Summary

Adult Wistar rats were exposed to carbon disulphide vapours at a concentration of 2.4 mg/l of air for 5 days a week (6 h a day), and the ultrastructure of Pacinian corpuscles and their nerve supply was investigated after 6 months of exposure. Both degenerative and regenerative changes were observed in sensory axons and the corpuscles. In a sample of corpuscles examined, 30% were denervated and about 60% showed clear signs of reinnervation. Some of the reinnervated corpuscles were supplied by unmyelinated axons. In others, one to three myelinated axons were already found at the nerve entry. The axons branched and formed three to eight terminals in the inner core. Due to continuous intoxication, most regenerated terminals were again undergoing degeneration. In peripheral nerves, the evidence of axonal regeneration has been reported in various toxic distal axonopathies. However, the reinnervation of Pacinian corpuscles has not been described before. It can be expected that reinnervation of Pacinian corpuscles and other end-organs also occurs in other axonopathies, if not during continuous poisoning, then at least after its cessation.

Key words

Carbon disulphide neuropathy Pacinian corpuscles Denervation and reinnervation Electron microscopy 

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References

  1. Cavanagh JB (1964) Peripheral nerve changes in ortho-cresyl phosphate poisoning in the cat. J Pathol Bacteriol 87:365–383Google Scholar
  2. Colombi A, Maroni M, Picchi O, Rota E, Castano P, Foa V (1981) Carbon disulphide neuropathy in rats. A morphological and ultrastructural study of degeneration and regeneration. Clin Toxicol 18:1463–1474Google Scholar
  3. Fullerton PM, Barnes JM (1966) Peripheral neuropathy in rats produced by acrylamide. Br J Ind Med 23:210–221Google Scholar
  4. Halata Z (1975) Mechanoreceptors of the mammalian skin. Ultrastructure and morphological classification. Adv Anat Embryol Cell Biol. Springer, Berlin 50: 1–77Google Scholar
  5. Hopkins AP (1968) Experimental neuropathy in the baboon. MD thesis, University of London, LondonGoogle Scholar
  6. Hopkins AP (1970) The effect of acrylamide on the peripheral nervous system in the baboon. J Neurol Neurosurg Psychiatry 33:805–816Google Scholar
  7. Hunt CC (1974) The Pacinian corpuscle. In: Hubbard JI (ed) The peripheral nervous system. Plenum Press, London, pp 374–404Google Scholar
  8. Jirmanová I, Lukáš E (1984) Ultrastructure of carbon disulphide neuropathy. Acta Neuropathol (Berl) 63:255–263Google Scholar
  9. Juntunen J, Linnoila MD, Haltia M (1977) Histochemical and electron-microscopic observations on the myoneural junctions of rats with carbon disulphide induced polyneuropathy. Scand J Work Environ Health 3:36–42Google Scholar
  10. Linnoila I, Haltia M, Seppäläinen AM, Palo J (1975) Experimental carbon disulphide poisoning: morphological and neurophysiological studies. In: Környey S, Tariska ST, Gosztonyi G (eds) Proceedings of the VIIth International Congress of Neuropathology. Excerpta Medica, Amsterdam, pp 383–386Google Scholar
  11. Lukáš E (1969) Leitgeschwindigkeit peripherer Nerven bei Schwefelkohlenstoff ausgesetzten Personen. Int Z Klin Pharmakol Ther Toxikol 2:354–358Google Scholar
  12. Malinovský L, Páč L (1982) Morphology of sensory corpuscles in mammals. Acta Fac Med Univ Brun 79:1–219Google Scholar
  13. Manu P, Lilis R, Lancrajan I, Ionescu S, Vasilescu I (1970) The value of electromyographic changes in the early diagnosis of carbondisulphide peripheral neuropathy. Med Lav 61:102–107Google Scholar
  14. Ohnishi A, Peterson CM, Dyck PJ (1975) Axonal degeneration in sodium cyanate-induced neuropathy. Arch Neurol 32:530–534Google Scholar
  15. Otelin AA, Mashansky VF, Mirkin AS (1976) Teltse Vater-Pacini Nauka, Leningrad, p 175Google Scholar
  16. Savolainen H (1977) Some aspects of the mechanisms by which industrial solvents produce neurotoxic effects. Chem Biol Interact 18:1–9Google Scholar
  17. Seppäläinen AM, Haltia M (1980) Carbon disulphide. In: Spencer PS, Schaumburg EE (eds) Experimental and clinical neurotoxicology. Williams and Wilkins, Baltimore, pp 356–373Google Scholar
  18. Seppäläinen AM, Tolonen M, Karli P, Hänninen H, Hernberg S (1972) Neurophysiological findings in chronic carbondisulphide poisoning: a descriptive study. Work Environ Health 9:71–75Google Scholar
  19. Schlaepfer WW, Hager H (1964) Ultrastructural studies of INH-induced neuropathy in rats. 1. Early axonal changes. Am J Pathol 45:209–219Google Scholar
  20. Spencer PS, Schaumburg HH (1974) A review of acrylamide neurotoxicity. Part II. Experimental animal neurotoxicity and pathologic mechanisms. Can J Neurol Sci 1:152–168Google Scholar
  21. Spencer PS, Schaumburg HH (1975) Experimental neuropathy produced by 2,5-hexanedione. A major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone. J Neurol Neurosurg Psychiatry 38:771–775Google Scholar
  22. Spencer PS, Thomas PK (1974) Ultrastructural studies of the dying-back processes. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons. J Neurocytol 3:763–783Google Scholar
  23. Spencer PS, Sabri MI, Schaumburg HH, Moore EC (1979) Does a defect of energy metabolism in the nerve fiber underlie axonal degeneration in polyneuropathies? Ann Neurol 5:501–509Google Scholar
  24. Szendzikowski S, Stetkiewicz J, Wroňska-Noffer T, Karasek M (1973) Structural aspects of the experimental carbon disulphide neuropathy. I. Development of neurohistological changes in chronically intoxicated rats. Int Arch Arbeitsmed 31:135–149Google Scholar
  25. Szendzikowski S, Stetkiewicz J, Wroňska-Noffer T, Karasek M (1974) Pathomorphology of the experimental lesion of the peripheral nervous system in white rats chronically exposed to carbon disulphide. In: Hausmanowa-Petrusiewicz I, Jedrzejowska H (eds) Structure and function of normal and diseased muscle and peripheral nerve, Polish Medical Publishers, Warsaw, pp 319–326Google Scholar
  26. Suzuki K, Pfaff LD (1973) Acrylamide neuropathy in rats. Acta Neuropathol (Berl) 24:197–213Google Scholar
  27. Vasilescu C (1972) Motor nerve conduction velocity and electromyogram in carbondisulphide poisoning. Rev Roum Neurol Psychiatr 9:63–71Google Scholar
  28. Vasilescu C (1976) Sensory and motor conduction in chronic carbon disulphide poisoning. Eur Neurol 14:447–457Google Scholar
  29. Vigliani ECC (1954) Carbon disulphide poisoning in viscose rayon factories. Br J Ind Med 11:235–244Google Scholar
  30. Zelená J (1982) Survival of Pacinian corpuscles after denervation in adult rats. Cell Tissue Res 24:673–683Google Scholar
  31. Zelená J (1984) Multiple axon terminals in reinnervated Pacinian corpuscles of adult rat. J Neurocytol 13:665–684Google Scholar
  32. Zelená J, Sobotková M, Zelená H (1978) Age-modulated dependence of Pacinian corpuscles upon their sensory innervation. Physiol Bohemoslov 27:437–443Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • I. Jirmanová
    • 1
  1. 1.Institute of PhysiologyCzechoslovak Academy of SciencesPrague 4Czechoslovakia

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