Acta Neuropathologica

, Volume 69, Issue 1–2, pp 171–175 | Cite as

Severe cerebellar degeneration in a patient with T-cell lymphoma

  • L. C. Ang
  • D. W. Zochodne
  • G. C. Ebers
  • J. C. E. Kaufmann
  • H. V. Vinters
Short Original Communications


A 53-year-old man with an aggressive T-cell lymphoma was found at autopsy to have severe cerebellar degeneration, presumably as a ‘remote’ effect of malignancy. The degree of cerebellar atrophy was unusually pronounced and widespread, involving both Purkinje cell and granule cell layers, although patches of preserved and essentially normal cerebellar cortex were identified. This case is of particular interest in view of data which indicate that cerebellar Purkinje cells and T-lymphocytes share antigenic surface markers.

Key words

Cerebellum Degeneration Neoplasms, remote effects Lymphoma 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • L. C. Ang
    • 1
  • D. W. Zochodne
    • 1
  • G. C. Ebers
    • 1
  • J. C. E. Kaufmann
    • 1
  • H. V. Vinters
    • 1
  1. 1.Departments of Pathology and Clinical Neurological SciencesUniversity Hospital and University of Western OntarioLondonCanada

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