Cancer Chemotherapy and Pharmacology

, Volume 35, Supplement 1, pp S97–S100 | Cite as

Experiences with doxo/epirubicin and medroxyprogesterone acetate (MPA) in prostatic cancer

  • Claes Anderström
Session 4: State of the Art in Urinary Tract Tumors Epirubicin, Medroxyprogesterone Acetate, Prostatic Cancer


Maximal androgen blockade (MAB) has been reported to prolong the time to progression and the duration of survival in metastatic prostatic cancer. The addition of epirubicin to MAB in such patients seems to improve the therapeutic results further. The beneficial effect of combining castration with epirubicin in metastatic cases appears questionable. In comparing the time to progession in patients treated with MAB±epirubicin versus castration ±epirubicin or estramustine, many studies reveal similar figures. Whether the results after treatment are actually improved remains controversial. In hormone-refractory cases, medroxyprogesterone acetate (MPA) alone seems superior to estramustine or prednisolone treatment. Combining MPA and epirubicin improves the results, but even if the improvement is of clinical value, it is nonetheless of limited magnitude.

Key words

Epirubicin Medroxyprogesterone acetate Prostatic cancer 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Claes Anderström
    • 1
  1. 1.Department of UrologyKärnsjukhusetSkövdeSweden

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