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Cancer Chemotherapy and Pharmacology

, Volume 35, Issue 6, pp 506–510 | Cite as

Continuous mitoxantrone infusion in pretreated epithelial ovarian cancer

  • M. O. Nicoletto
  • R. Padrini
  • H. Koussis
  • A. Rosabian
  • S. Aversa
  • L. Endrizzi
  • P. Azzoni
  • M. Palumbo
  • M. V. Fiorentino
Original Article Mitoxantrone Infusion, Advanced Epithelial Ovarian Cancer, Mitoxantrone Stability

Abstract

Mitoxantrone has shown moderate activity in advanced epithelial ovarian cancer following intermittent i.v. administration. Experiments and clinical data suggest that long-term continuous drug infusion may achieve a better therapeutic result with less toxicity. This hypothesis was tested in patients with advanced ovarian cancer who had been pretreated with other agents. Mitoxantrone was infused continuously in 21-day courses beginning every 6 weeks. If severe toxicity did not occur, the infusion rate was increased by 0.1–0.2 mg/m2 per day. The mitoxantrone solution proved to be stable over the 21-day infusion period. For ethical reasons an optimal two-stage design was employed. The trial was interrupted at the end of the first recruitment stage because the target of 3 responses out of 13 patients had not been achieved (only 1 patient had a partial response). Hematologic toxicity was observed in 11 patients, and 2 of them had a catheter occlusion. In conclusion, we found that 21-day of infusion of mitoxantrone apparently has no clinical benefit as compared with bolus administration in patients with advanced ovarian cancer.

Key words

Mitoxantrone infusion Advanced epithelial ovarian cancer Mitoxantrone stability 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. O. Nicoletto
    • 1
  • R. Padrini
    • 2
  • H. Koussis
    • 1
  • A. Rosabian
    • 3
  • S. Aversa
    • 1
  • L. Endrizzi
    • 4
  • P. Azzoni
    • 5
  • M. Palumbo
    • 6
  • M. V. Fiorentino
    • 1
  1. 1.Medical Oncology DepartmentPadova General HospitalPadovaItaly
  2. 2.Department of PharmacologyUniversity of PadovaPadovaItaly
  3. 3.Medical Oncology DepartmentThiene-Schio General HospitalVicenzaItaly
  4. 4.Medical Oncology DepartmentBassano General HospitalVicenzaItaly
  5. 5.Medical DepartmentBussolengo HospitalVeronaItaly
  6. 6.Department of Pharmaceutical SciencesUniversity of PadovaPadovaItaly

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