Advertisement

Acta Neuropathologica

, Volume 75, Issue 1, pp 85–91 | Cite as

The angiogenesis of the micrencephalic rat brains caused by methylazoxymethanol acetate

III. Internal angioarchitecture of cortex
  • A. Bardosi
  • G. Ambach
  • P. Hann
Regular Papers

Summary

The intracortical angioarchitecture of normal and micrencephalic rat brains was examined. The neuroblast migration was disturbed by injection of the neurotoxin methylazoxymethanol acetate, administered on day E14. The internal vascularization of the malformed cortex showed severe damage to the layered distribution of vascular trunks in contrast to controls. A pathological course and marked variability in the density of the radial vessels were seen in the parieto-occipital areas, in which the neuroblast migration was most severely affected. These observations show the decisive role of neuroblast migration and maturation in the development of the cortical angioarchitecture.

Key words

Angiogenesis Micrencephaly Methylazoxymethanol acetate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ambach G, Palkovits M (1974) Blood supply of the rat hypothalamus. I. Nucleus supraopticus. Acta Morphol Hung 22:291–310Google Scholar
  2. 2.
    Ambach G, Toldi J, Fehér O, Joó F, Wolff JR (1986) Spatial correlation between sensory regions and the drainage fields of pial veins in rat cerebral cortex. Exp Brain Res 61:540–548Google Scholar
  3. 3.
    Ashwell KWS, Webster WS (1986) Increased vascularity and alterations in cytochrome oxidase distribution associated with abnormal hippocampal cytoarchitecture in micrencephalic rats. Dev Brain Res 30:31–36Google Scholar
  4. 4.
    Bardosi A, Ambach G (1985) Constant position of the superficial cerebral veins of the rat: a quantitative analysis. Anat Rec 211:338–341Google Scholar
  5. 5.
    Bardosi A, Ambach G, Friede RL (1985) The angiogenesis of micrencephalic rat brains caused by methylazoxymethanol acetate. I. Superficial venous system. A quantitative analysis. Acta Neuropathol (Berl) 66:253–263Google Scholar
  6. 6.
    Bardosi A, Ambach G, Friede RL (1985) The angiogenesis of micrencephalic rat brains caused by methylazoxymethanol acetate. II. Superficial and basal arterial system. Acta Neuropathol (Berl) 68:59–64Google Scholar
  7. 7.
    Bär T (1980) The vascular system of the cerebral cortex. Adv Anat Embryol Cell Biol 59:1–54Google Scholar
  8. 8.
    Chen S, Hillmann DE (1986) Selective ablation of neurons by methylazoxymethanol during pre- and postnatal brain development. Exp Neurol 94:103–119Google Scholar
  9. 9.
    Craigie EH (1921) The vascularity of the cerebral cortex of the albino rat. J Comp Neurol 33:193–212Google Scholar
  10. 10.
    Dambska M, Haddad R, Kozlowski PB, Lee MH, Shek J (1982) Telencephaly cytoarchitectonics in the brains of rats with graded degrees of micrencephaly. Acta Neuropathol (Berl) 58:203–209Google Scholar
  11. 11.
    Duvernoy HM, Delon S, Vannson JL (1981) Cortical blood vessels of the human brain. Brain Res Bull 7:519–579Google Scholar
  12. 12.
    Eulner S (1980) Beziehungen zwischen Wachstum und Vaskularisation der Großhirnrinde. Eine morphometrische Studie an der Albinoratte. Medical Thesis, University Göttingen, FRGGoogle Scholar
  13. 13.
    Johnston MV, Coyle JT (1979) Histological and neurochemical effects of fetal treatment with methylazoxy methanol on rat neocortex in adulthood. Brain Res 170: 135–155Google Scholar
  14. 14.
    Johnston MV, Coyle JT (1980) Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate. J Neurochem 34:1429–1441Google Scholar
  15. 15.
    Nakai K, Imai H, Kamei I, Itakura T, Komari N, Kimura H, Nagai T, Maeda T (1981) Microangioarchitecture of rat parietal cortex with special reference to vascular “sphincters”. Stroke 12:653–659Google Scholar
  16. 16.
    Rudolph K (1986) Topographische Zusammenhänge zwischen extra-und intracerebralen Blutgefäßen am Neocortex der Ratte. Biol Fak TübingenGoogle Scholar
  17. 17.
    Singh SC (1977) Ectopic neurons in the hippocampus of the postnatal rat exposed to methylazoxymethanol during fetal development. Acta Neuropathol (Berl) 40:111–116Google Scholar
  18. 18.
    Singh SC (1980) Deformed dendrites and reduced spine numbers on ectopic neurones in the hippocampus of rats exposed to methylazoxymethanol-acetate. Acta Neuropathol (Berl) 49:193–198Google Scholar
  19. 19.
    Strong LH (1964) The early embryonic pattern of internal vascularization of the mammalian cerebral cortex. J Comp Neurol 123:121–138Google Scholar
  20. 20.
    Wolff JR (1978) Ontogenetic aspects of cortical architecture: lamination. In: Brazier MAB, Petsche H (eds) Architectonics of the cerebral cortex. Raven Press. New York, pp 159–173Google Scholar
  21. 21.
    Wolff JR (1981) Some morphogenetic aspects of the development of the central nervous system. In: Behav Dev, Immelmann K, Barlow GW, Petrinovich L, Main M (eds) The Bielefeld interdisciplinary project. Cambridge University Press. New York pp 164–190Google Scholar
  22. 22.
    Wolff JR, Goerz C, Bär T, Güldner FH (1975) Common morphogenetic aspects of various organotypic microvascular patterns. Microvasc Res 10:373–395Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Bardosi
    • 1
  • G. Ambach
    • 2
  • P. Hann
    • 1
  1. 1.Abteilung NeuropathologieUniversität GöttingenGöttingenFederal Republic of Germany
  2. 2.Abteilung PsychiatrieUniversität WürzburgWürzburgFederal Republic of Germany

Personalised recommendations