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Acta Neuropathologica

, Volume 15, Issue 3, pp 279–383 | Cite as

Sur une polioencéphalopathie progressive avec dégénérescences neurofibrillaires

  • O. Bugiani
  • A. Agnoli
Communications Originales Brèves

Resumé

Une affection neurologique caracterisée par l'atteinte de nombreux nerfs craniens, des signes pyramidaux, des troubles de la sensibilité profonde, de la torpeur et de la désorientation, se présente chez une femme alcoolique âgée de 46 ans. Evolution en sept mois. Histologiquement: polioencéphalopathie avec plaques argyrophiles, dégénérescences neurofibrillaires et lipopigmentaires, sans raréfaction neuronale. Les formations les plus intéressées sont l'écorce hippocampique et les noyaux de la calotte mésencéphalique. La substance blanche du centre ovale et les faisceaux pyramidaux et postérieurs participent au processus.

Progressive polioencephalopathy with neurofibrillary degeneration

Summary

A case is presented of an alcoholic woman aged 46, with a progressive impairment of cranial nerves, bilateral pyramidal signs and involvement of deep sensation, clouding of the sensorium and loss of orientation. The disease run a fatal course in seven months. Histological examination disclosed a polioencephalopathy with argyrophilic plaques, neurofibrillary degeneration and accumulation of lipofuscin, without neuronal loss. Such changes were mostly evident in the hippocampal cortex and tegmental nuclei at midbrain level. White substance of centrum ovale, pyramidal tracts and posterior columns were also affected.

Key-Words

Neurofibrillary Degeneration Argyrophilic Plaques Lipopigment Degeneration Polioencephalopathy 

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Copyright information

© 1970 1970

Authors and Affiliations

  • O. Bugiani
    • 1
  • A. Agnoli
    • 1
  1. 1.Istituto di Clinica delle Malattie nervose e mentali dell'Università di GenovaGenovaItalie

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