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Prospective and randomized controlled study of chemoembolization therapy in patients with advanced hepatocellular carcinoma

  • Clinical Aspects in the Treatment for Operable and Session II. Chemotherapy and Radiotherapy II. 1. TAE-2
  • Transcatheter Arterial Embolization, Chemoembolization, Hepatocellular Carcinoma
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Abstract

The Cooperative Study Group conducted a study to assess the therapeutic effects of chemoembolization in patients with advanced hepatocellular carcinoma (HCC) using either epirubicin hydrochloride (FARM) or doxorubicin hydrochloride (ADR). A total of 77 patients were enrolled in this study and randomized into 2 groups: 39 patients were treated with a FARM solution as the material for Lipiodol-transcatheter arterial embolization (TAE; FARM group), and 38 patients were treated with an ADR solution as the material for L-TAE (ADR group). For the FARM group, the 1-year survival rate was 69.9% and the 2-year survival rate was 44.5%. For the ADR group, the corresponding survival rates were 74.7% and 44.0%. The differences among the above figures were not statistically significant. As side effects, fever, nausea, and generalized fatigue occurred at almost the same frequencies in the two groups. Changes detected in the liver function and the peripheral blood cell count in both groups were not severe. There was no significant difference between the toxic effects observed in the two groups. In conclusion, there was no significant difference in therapeutic efficacy between the FARM and ADR groups.

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Authors and Affiliations

  1. 3rd Department of Internal Medicine, Ehime University School of Medicine, Ehime Prefecture, Japan

    Yasuyuki Ohta

  2. Department of Pharmacology, Ehime University School of Medicine, Ehime Prefecture, Japan

    Nobuya Ogawa

  3. 2nd Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima Prefecture, Japan

    Susumu Ito

  4. 1st Department of Internal Medicine, Kochi Medical School, Kochi Prefecture, Japan

    Yasutake Yamamoto

  5. The 3rd Department of Internal Medicine, Kagawa Medical School, 1750-1 Ikenobe, Miki-cho, 761-07, Kitagun, Kagawa, Japan

    Seishiro Watanabe & Mikio Nishioka

Authors
  1. Seishiro Watanabe
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  2. Mikio Nishioka
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  3. Yasuyuki Ohta
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  4. Nobuya Ogawa
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  5. Susumu Ito
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  6. Yasutake Yamamoto
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Cooperative Study Group for Liver Cancer Treatment in Shikoku area

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Watanabe, S., Nishioka, M., Ohta, Y. et al. Prospective and randomized controlled study of chemoembolization therapy in patients with advanced hepatocellular carcinoma. Cancer Chemother. Pharmacol. 33 (Suppl 1), S93–S96 (1994). https://doi.org/10.1007/BF00686676

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  • DOI: https://doi.org/10.1007/BF00686676

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