Acta Neuropathologica

, Volume 8, Issue 1, pp 47–56 | Cite as

Scrapie in the rat: an electron-microscope study

I. Amyloid bodies and deposits
  • E. J. Field
  • C. S. Raine
  • Greta Joyce


Both well formed amyloid bodies showing clear concentric lamination and smaller masses of amyloid material have been found in the brains of rats suffering from scrapie. Amyloid appears to form within astrocyte processes and glial cell bodies, as well as shrunken nerve cells. Rarely, it was present in degenerate axis cylinders. The individual fibrils which make up amyloid deposits appeared to have a spiral constitution, and deposits large enough to be seen in the light microscope were commonly strikingly symmetrically located.


Fibril Glial Cell Cell Body Nerve Cell Small Masse 
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In den Gehirnen von Scrapie-kranken Ratten wurden wohlgeformte Amyloidkörperchen mit deutlicher konzentrischer Schichtung und kleinere amyloide Massen gefunden. Amyloid scheint sich in Astrocytenfortsätzen und Gliazellkörpern sowie in geschrumpften Nervenzellen zu bilden. Selten ist es in degenerierten Achsenzylindern vorhanden. Die Einzelfibrillen, welche die Amyloidablagerungen aufbauen, scheinen spiralige Form zu haben. Die großen im Lichtmikroskop sichtbaren Ablagerungen sind gewöhnlich auffallend symmetrisch im Gehirn lokalisiert.


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Copyright information

© Springer-Verlag 1967

Authors and Affiliations

  • E. J. Field
    • 1
  • C. S. Raine
    • 1
  • Greta Joyce
    • 1
  1. 1.Medical Research Council, Demyelinating Diseases Research UnitRoyal Victoria Infirmary and University of Newcastle-upon-TyneNewcastle upon Tyne 2England

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