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Lithium pharmacokinetics during cisplatin-based chemotherapy: a case report

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  • Lithium Pharmacokinetics, Cisplatin, Chemotherapy
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Abstract

A 33-year-old patient, treated for several years with lithium carbonate for a manic depressive disorder, received four courses of combination chemotherapy (bleomycin, etoposide, cisplatin) after the diagnosis of disseminated testicular cancer. Lithium therapy was continued throughout all the courses. Serum and urine lithium concentrations were determined during and between all chemotherapy courses. During the first course a transient 64% decrease in serum lithium concentrations was found. This effect became less pronounced during the consecutive courses. The changes in serum lithium concentrations were without perceptible clinical significance. However, careful monitoring of serum lithium concentrations is mandatory in patients treated with cisplatin-based chemotherapy, as this is accompanied by profound disturbances of lithium pharmacokinetics.

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References

  1. Amidsen A, Carson SW (1986) Lithium. In: Evans WE, Schentag JJ, Jusko WJ, Harrison H (eds) Applied pharmacokinetics: principles of therapeutic drug monitoring, 2nd edn. Applied Therapeutics, San Francisco, pp 978–1008

    Google Scholar 

  2. Beijnen JH, Vlasveld LT, Wanders J, ten Bokkel Huinink WW, Rodenhuis S (1992) Effect of cisplatin-containing chemotherapy on lithium serum concentrations. Ann Pharmacother 26:488–490

    Google Scholar 

  3. Borch RF, Pleasant ME (1979) Inhibition of cisplatinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model. Proc Natl Acad Sci USA 76:6611–6614

    Google Scholar 

  4. Judd LL (1991) The therapeutic use of psychotropic medications. In: Wilson JD, Braunwald E, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, Root RK (eds) Principles of internal medicine, 12th edn. McGraw-Hill, New York, pp 2139–2146

    Google Scholar 

  5. Pietruszka LJ, Biermann WA, Vlasses PH (1985) Evaluation of cisplatin-lithium interaction. Drug Intell Clin Pharm 19:31–32

    Google Scholar 

  6. Schou M, Amidsen A, Baastrup PC (1971) The practical management of lithium treatment. Br J Hosp Med 6:53–60

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacy, Slotervaart Hospital/Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands

    J. H. Beijnen

  2. Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    J. H. Beijnen, E. M. Bais & W. W. ten Bokkel Huinink

Authors
  1. J. H. Beijnen
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  2. E. M. Bais
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  3. W. W. ten Bokkel Huinink
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Beijnen, J.H., Bais, E.M. & ten Bokkel Huinink, W.W. Lithium pharmacokinetics during cisplatin-based chemotherapy: a case report. Cancer Chemother. Pharmacol. 33, 523–526 (1994). https://doi.org/10.1007/BF00686512

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  • DOI: https://doi.org/10.1007/BF00686512

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