Acta Neuropathologica

, Volume 76, Issue 5, pp 484–488 | Cite as

Reverse pinocytosis induced in cerebral endothelial cells by injection of histamine into the cerebral ventricle

  • E. Dux
  • T. Dóczi
  • F. Joó
  • P. Szerdahelyi
  • L. Siklós
Regular Papers


Histamine dihydrochloride (10 μg of 500 μg/ml) was infused during 1 min into the lateral cerebral ventricle of rats, which resulted in a significant stimulation of pinocytosis in the endothelial cells. Systemic injections of mepyramine or metiamide could not prevent this activation. In contrast, ranitidine, injected with histamine was able to inhibit the stimulation of pinocytosis. Albumin exudation from the blood was not found. There was also no change in water and electrolyte contents of the brain tissue. The results suggest that histamine reaching the abluminal membrane can activate the pinocytosis in the cerebral endothelial cells in the reverse direction, i.e., from brain to blood, without opening the blood-brain barrier.

Key words

Histamine Cerebral ventricle Pinocytosis Brain-blood barrier 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • E. Dux
    • 1
  • T. Dóczi
    • 2
  • F. Joó
    • 1
  • P. Szerdahelyi
    • 3
  • L. Siklós
    • 1
  1. 1.Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research CenterHungarian Academy of SciencesSzegedHungary
  2. 2.Department of NeurosurgeryMedical SchoolSzegedHungary
  3. 3.Central Research LaboratoryMedical SchoolSzegedHungary

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