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Acta Neuropathologica

, Volume 7, Issue 3, pp 261–274 | Cite as

Microglia cells in diffuse and granulomatous encephalitis in the rabbit

  • Jan Cammermeyer
Original Investigations

Summary

The reactive changes of microglia cells were studied in encephalitic foci in different regions by a quadruple staining method for the demonstration of microglia cells and oligodendrocytes, vascular walls, myelin sheaths and neuronal contours.

On the basis of the microscopic changes of the silver impregnated microglia cells, it is inferred that (1) the perikarya and processes become enlarged or hypertrophied because of loss of support from the intervening tissue, (2) the pronounced vesiculation of cytoplasm and the aggregation of PAS-red-stained perticles are an expression of phagocytosis, pinocytosis and/or altered cell metabolism, and (3) the increase in number of microglia cells is associated with mitotic division of a juxtavascular histiocyte. There is no microscopic evidence suggestive of (1) migratory activity, or (2) mitotic division of microglia cells. The present material is not suited for a discussion of the relationship between microglia cells and “gitter” cells or allied cell types.

Keywords

Public Health Encephalitis Microglia Cell Vascular Wall Cell Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

La réaction des cellules de microglie a été étudiée dans des foyers encéphalitiques de différentes régions par une méthode quadruple de coloration pour la démonstration des cellules de microglie et des oligodendroglies, des parois vasculaires, de la myéline et des contours des neurones.

Après l'étude des altérations complexes des cellules de microglie impregnées, il est déduit que (1) le soma cellulaire et les prolongements deviennent agrandis ou hypertrophiés à cause de la perte du soutien du tissu intermédiaire, (2) la vésiculation prononcée du cytoplasme et l'aggrégation des granulations colorées par PAS font part d'une manifestation de la phagocytose, de la pinocytose ou de la métabolisme modifiée, et (3) l'augmentation dans la quantité des cellules de microglie est le résultat de la mitose d'une histiocyte juxtavasculaire. Il n'y a pas de preuve microscopique (1) d'un pouvoir migratoire, ou (2) de la mitose dans une cellule de microglie. Le matériel étudié ne s'adapt pas à une discussion du rapport entre les cellules de microglie et les «Gitterzellen» ou des types alliés.

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Copyright information

© Springer-Verlag 1967

Authors and Affiliations

  • Jan Cammermeyer
    • 1
  1. 1.Laboratory of Neuropathology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, U. S. Public Health ServiceDepartment of Health, Education and WelfareBethesda

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