Skip to main content
SpringerLink
Log in

Carboplatin and vinblastine in advanced non-small-cell lung cancer: a phase II study

  • Original Articles
  • Carboplatin, Vinblastine, Non-Small-Cell Lung Cancer
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

Between July 2, 1987, and August 21, 1987, Cancer and Leukemia Group B (CALGB) conducted a phase II evaluation of carboplatin (CBDCA) and vinblastine (VBL) in advanced non-small-cell lung cancer. Of the 58 patients who entered the study, 55 were eligible and produced follow-up data. Chemotherapy, which was carried out in 28-day cycles, consisted of 4 mg/m2 VBL given on days 1 and 3 and 125 mg/m2 CBDCA given on days 1–3. Partial responses were observed in 10 cases (18%), and 1 patient (2%) exhibited regression of evaluable disease. No complete responses were achieved. The overall objective response rate was 20%. The median survival was 6.1 months, and the median time to treatment failure was 3.3 months. Life-threatening (grade 4) toxicity was mainly leukopenia (20%), followed by anemia (7%), infection (4%), thrombocytopenia (2%), fever (2%), nausea and vomiting (2%), and weight loss (2%). There were two deaths due to infection. The results of this study demonstrate that the combination CBDCA/VBL is active in advanced NSCLC; however, whether this combination is more active than either CBDCA or VBL alone is unknown.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Blumenreich MS, Woodcock TM, Gentile PS, Barnes GV, Vose B, Sherrill EJ, Richman SP, Epremian BE, Kubota TT, Allegra JC (1987) High-dose cisplatin and vinblastine infusion with or without radiation therapy in patients with advanced non-small cell lung cancer. J Clin Oncol 5: 1725–1730

    Google Scholar 

  2. Bonomi PD, Finkelstein DM, Ruckdeschel JC, Blum RH, Green MD, Mason B, Hahn R, Tormey DC, Harris J, Comis R, Glick J (1989) Combination chemotherapy versus single agents followed by combination chemotherapy in stage IV non-small cell lung cancer: a study of the Eastern Cooperative Oncology Group. J Clin Oncol 7: 1602–1613

    Google Scholar 

  3. Bunn PA Jr (1989) The expanding role of cisplatin in the treatment of non-small cell lung cancer. Semin Oncol 16 [Suppl]: 10–21

    Google Scholar 

  4. Bunn PA Jr (1989) Review of therapeutic trials of carboplatin in lung cancer. Semin Oncol 16: [Suppl]: 27–33

    Google Scholar 

  5. Ganz PA, Figlin RA, Haskell CM, LaSoto N, Sian J (1989) Supportive care versus supportive care and combination chemotherapy in metastatic non-small lung cancer: does chemotherapy make a difference? Cancer 63: 1271–1278

    Google Scholar 

  6. Gatzemeier U, Heckmayr M, Neuhauss R, Hossfeld D, Achterrath W, Lenaz L (1990) Phase II studies with carboplatin in nonsmall cell lung cancer. Semin Oncol 17 [Suppl]: 25–31

    Google Scholar 

  7. Kalbfleisch JD, Prentice RL (1980) The statistical analysis of failure time data. (Wiley series in probability and mathematical statistics) John Wiley and Sons, New York

    Google Scholar 

  8. Kaplan EL, Meier RL (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457–481

    Google Scholar 

  9. Klastersky J, Sculier JP, Bureau G, Libert P, Ravez P, Vandermoten G, Thinlaux V, Lecomte J, Cordier R, Dabouis G, Brohée D, Thèmelin L, Mommen P (1989) Cisplatin versus cisplatin plus etoposide in the treatment of advanced non-small cell lung cancer. J Clin Oncol 7: 1087–1092

    Google Scholar 

  10. Kreisman H, Ginsberg S, Propert KJ, Richards F, Graziano S, Green M (1987) Carboplatin or iprolatin in advanced non-small cell lung cancer: a cancer and Leukemia Group B study. Cancer Treat Rep 71: 1049–1052

    Google Scholar 

  11. Mehta CR, Patel NR (1983) A network algorithm for the exact treatment of Fisher's exact test in RxC contingency tables. J Am Stat Assoc 78: 382, 427–434

    Google Scholar 

  12. Rapp E, Pater JL, Willan A, Cormièr Y, Murray N, Evans WK, Hodson DI, Clark DA, Feld R, Arnold AM, Ayoub VI, Wilson KS, Latreille V, Wierzbicki RF, Hill DP (1988) Chemotherapy can prolong survival in patients with advanced non-small cell lung cancer — report of a Canadian multicenter randomized trial. J Clin Oncol 6: 633–641

    Google Scholar 

  13. Rosell R, Abad-Esteve A, Moreno I, Barnadas A, Carles J, Fermandez C, Ribelles N, Culubret M (1990) A randomized study of two vindesine plus cisplatin-containing regimens with the addition of mitomycin C or ifosfamide in patients with advanced non-small cell lung cancer. Cancer 65: 1692–1699

    Google Scholar 

  14. Williams CJ, Woods R, Levi J, Page J (1988) Chemotherapy for non-small cell lung cancer: a randomized trial of cisplatin/vindesine vs no chemotherapy. Semin Oncol 15 [Suppl]: 58–61

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biostatistics, Harvard School of Public Health, Boston, MA

    M. Goutsou

  2. Department of Medicine, SUNY Health Science Center, Syracuse, NY

    S. Graziano

  3. Southern Nevada Cancer Research Foundation, CCOP, Las Vegas, NV

    J. Ellerton

  4. Department of Medicine, University of Chicago, Chicago, IL

    J. Bitran

  5. Frontier Science Technology and Research Foundation, Amhurst, NY

    C. Modeas

  6. Department of Biostatistics, Duke University Medical Center Durham, North Carolina

    J. Herndon

  7. Department of Medicine, University of Missouri, Columbia, MO

    M. Perry

  8. Department of Medicine and Cancer Center, University of California at San Diego, San Diego, CA

    M. Green

  9. Department of Medicine, University of Missouri, 65201, Columbia, MO, USA

    D. Doll

Authors
  1. D. Doll
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Goutsou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Graziano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Ellerton
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Bitran
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Modeas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Herndon
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M. Perry
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. Green
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Doll, D., Goutsou, M., Graziano, S. et al. Carboplatin and vinblastine in advanced non-small-cell lung cancer: a phase II study. Cancer Chemother. Pharmacol. 29, 71–74 (1991). https://doi.org/10.1007/BF00686339

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00686339

Keywords

Search

Navigation