Cancer Chemotherapy and Pharmacology

, Volume 29, Issue 1, pp 61–65 | Cite as

A phase I trial of continuous-infusion cyclophosphamide in refractory cancer patients

  • Joseph P. Eder
  • Anthony D. Elias
  • Lois Ayash
  • Catherine A. Wheeler
  • Thomas C. Shea
  • Lowell E. Schnipper
  • Emil FreiIII
  • Karen H. Antman
Original Articles Cyclophosphamide, Continuous Infusion, Refractory Cancer


Cyclophosphamide demonstrates enhanced tumoricidal activity with decreased bone marrow toxicity when given on a divided-dose schedule in certain animal models. A total of 22 patients presenting with refractory metastatic cancer were treated in a phase I trial of continuous infusion of cyclophosphamide over 96 h. Granulocytopenia of <500/μl that lasted for > 14 days or thrombocytopenia of <25,000/μl that lasted for > 14 days was the target dose-limiting toxicity in the absence of nonhematologic grade 4 toxicity. The maximal tolerated dose was 7 g/m2. Three patients died. Of 21 evaluable patients, 9 responded, including 8/9 who had experienced disease progression during prior oxazaphosphorine-containing combination chemotherapy. Clinically meaningful responses were observed in patients who had demonstrated clinical resistance to an oxazaphosphorine drug given at lower doses.


Bone Marrow Cancer Patient Cyclophosphamide Thrombocytopenia Continuous Infusion 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Joseph P. Eder
    • 1
    • 2
  • Anthony D. Elias
    • 3
  • Lois Ayash
    • 3
  • Catherine A. Wheeler
    • 1
  • Thomas C. Shea
    • 3
  • Lowell E. Schnipper
    • 1
  • Emil FreiIII
    • 3
  • Karen H. Antman
    • 3
  1. 1.The Department of MedicineBeth Israel HospitalBoston
  2. 2.Thorndike Laboratories of the Charles A. Dana Research InstituteBeth Israel HospitalBoston
  3. 3.Department of MedicineDana-Farber Cancer Institute Harvard Medical SchoolBoston

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