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Scambia G, Ranelletti FO, Panici PB, De Vincenzo R, Bonnano G, Ferrandina G, Piantelli M, Bussa S, Rumi C, Cianfriglia M, Mancuso S (1994) Quercetin potentiates the effect of Adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol 34: 459–464
Kolars JC, Ren PS, Schuetz JD, Fang C, Watkins PB (1992) Identification of rifampin inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. J Clin Invest 90:1871–1878
Bailey DG, Spence JD, Munoz C, Arnold JMO (1991) Interaction of citrus juices with felodopine and nifedipine. Lancet 337:268–269
Edgar B, Bailey DG, Bergstrand R, Johnsson G, Regardh CG (1992) Acute effect of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine and its potential clinical relevance. Eur J Clin Pharmacol 42:313–317
Soons PA, Vogels BAPM, Roosemalen MCM, et al. (1991) Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in man. Clin Pharmacol Ther 50:394–403
Bailey DG, Malcolm J, Arnold O, Strong A, Munoz C, Spence DJ (1993) Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin Pharmacol Ther 54:589–594
Minisalco A, Lundahl J, Regardh, CG, Edgar B, Erisksson UG (1992) Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J Pharmacol Exp Ther 261:1195–1199
Zhou XJ, Xhou PX, Gautheir T, Placidi M, Maurel P, Rahmani R (1993) Human liver microsomal cytochrome P4503A isozymes mediated vindesine biotransformation — metabolic drug interactions. Biochem Pharmacol 45:853–861
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Sarkar, M.A. Quercetin not only inhibits P-glycoprotein efflux activity but also inhibits CYP3A isozymes. Cancer Chemother. Pharmacol. 36, 448–449 (1995). https://doi.org/10.1007/BF00686195
- Cancer Research
- Efflux Activity
- CYP3A Isozyme