Advertisement

Cancer Chemotherapy and Pharmacology

, Volume 36, Issue 5, pp 448–449 | Cite as

Quercetin not only inhibits P-glycoprotein efflux activity but also inhibits CYP3A isozymes

  • Mohamadi A. Sarkar
Letter to the Editors/Reply Quercetin, P-glycoprotein, CYP3A Isozymes

Keywords

Cancer Research Quercetin Efflux Activity CYP3A Isozyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Scambia G, Ranelletti FO, Panici PB, De Vincenzo R, Bonnano G, Ferrandina G, Piantelli M, Bussa S, Rumi C, Cianfriglia M, Mancuso S (1994) Quercetin potentiates the effect of Adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol 34: 459–464Google Scholar
  2. 2.
    Kolars JC, Ren PS, Schuetz JD, Fang C, Watkins PB (1992) Identification of rifampin inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. J Clin Invest 90:1871–1878Google Scholar
  3. 3.
    Bailey DG, Spence JD, Munoz C, Arnold JMO (1991) Interaction of citrus juices with felodopine and nifedipine. Lancet 337:268–269Google Scholar
  4. 4.
    Edgar B, Bailey DG, Bergstrand R, Johnsson G, Regardh CG (1992) Acute effect of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine and its potential clinical relevance. Eur J Clin Pharmacol 42:313–317Google Scholar
  5. 5.
    Soons PA, Vogels BAPM, Roosemalen MCM, et al. (1991) Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in man. Clin Pharmacol Ther 50:394–403Google Scholar
  6. 6.
    Bailey DG, Malcolm J, Arnold O, Strong A, Munoz C, Spence DJ (1993) Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin Pharmacol Ther 54:589–594Google Scholar
  7. 7.
    Minisalco A, Lundahl J, Regardh, CG, Edgar B, Erisksson UG (1992) Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J Pharmacol Exp Ther 261:1195–1199Google Scholar
  8. 8.
    Zhou XJ, Xhou PX, Gautheir T, Placidi M, Maurel P, Rahmani R (1993) Human liver microsomal cytochrome P4503A isozymes mediated vindesine biotransformation — metabolic drug interactions. Biochem Pharmacol 45:853–861Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Mohamadi A. Sarkar
    • 1
  1. 1.West Virginia UniversityMorgantownUSA

Personalised recommendations