Acta Neuropathologica

, Volume 70, Issue 3–4, pp 190–192 | Cite as

An autopsy case of dementia and parkinsonism with severe degeneration exclusively in the substantia nigra

  • K. Oyanagi
  • S. Nakashima
  • F. Ikuta
  • Y. Homma
Original Works


We have recently encountered a patient with progressive dementia and parkinsonism beginning at the age of 68 years and developing for 2 years. Pathological examination revealed severe degeneration exclusively in the substantia nigra with absence of Lewy bodies and neurofibrillary changes. The features of this case are reported and discussed.

Key words

Dementia Parkinsonism Substantia nigra 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Boller F, Mizutani T, Roessmann U, Gambetti P (1980) Parkinson disease, dementia, and Alzheimer disease: clinicopathological correlations. Ann Neurol 7:329–335Google Scholar
  2. 2.
    Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ (1983) A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra byN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 80: 4546–4550Google Scholar
  3. 3.
    Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ (1979) Chronic parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res 1:249–254Google Scholar
  4. 4.
    Gaspar P, Gray F (1984) Dementia in idiopathic parkinson's disease. A neurological study of 32 cases. Acta Neuropathol (Berl) 64:43–52Google Scholar
  5. 5.
    Hakim AM, Mathieson G (1979) Dementia in Parkinson disease: a neuropathologic study. Neurology 29:1209–1214Google Scholar
  6. 6.
    Heilig CW, Knopman DS, Mastri AR, Frey II W (1985) Dementia without Alzheimer pathology. Neurology 35: 762–765Google Scholar
  7. 7.
    Hirano A, Malamud N, Kurland LT (1961) Parkinsonismdementia complex, an endemic disease on the island of Guam. II. Pathological features. Brain 84:662–679Google Scholar
  8. 8.
    Lewin R (1985) Parkinson's disease: an environmental cause? Science 229:257–258Google Scholar
  9. 9.
    Mata M, Dorovini-zis K, Wilson M, Young AB (1983) New form of familial parkinson-dementia syndrome: clinical and pathologic findings. Neurology 33:1439–1443Google Scholar
  10. 10.
    Ohama E, Takeda S, Ikuta F (1984) Neuropathological examination of the experimental parkinsonism in the monkey by the administration ofN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuropathology 5:254 [Abstr]Google Scholar
  11. 11.
    Shoene WC (1985) Diseases of the mesencephalon involving the substantia nigra and related systems of neurons. In: Davis RL, Robertson DM (eds) Textbook of neuropathology. Williams & Wilkins, Baltimore, pp 798–804Google Scholar
  12. 12.
    Whitehouse PJ, Hedreen JC, White CL, Price DL (1983) Basal forebrain neurons in the dementia of Parkinson's disease. Ann Neurol 13:243–248Google Scholar
  13. 13.
    Yoshimura M (1983) Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”. J Neurol 229:17–32Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • K. Oyanagi
    • 1
  • S. Nakashima
    • 1
  • F. Ikuta
    • 1
  • Y. Homma
    • 2
  1. 1.Department of Pathology, Brain Research InstituteNiigata UniversityNiigataJapan
  2. 2.Department of NeurologySado General HospitalNiigataJapan

Personalised recommendations