Cancer Chemotherapy and Pharmacology

, Volume 34, Issue 4, pp 361–363 | Cite as

Response rates — An evolution

  • Elizabeth Poplin
  • Laurence Baker
Short Communication Response Rates, Chemotherapy Agents


The documented frequency of response of cancers to common chemotherapy agents and combinations appears to have decreased over the decades. Multiple reasons exist for this decline including: changes in eligibility and evaluability criteria; changes in the type of patients entered onto trial; and, altered criteria for response and methods for response assessment. The disinclination to publish negative results also permits a bias in a favor of overestimating a drug's efficacy. Circumspection now is advised in assessing data from older trials.

Key words

Response rates Chemotherapy agents 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Elizabeth Poplin
    • 1
  • Laurence Baker
    • 1
  1. 1.Division of Hematology and Oncology, Harper HospitalWayne State UniversityDetroitUSA

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