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Acta Neuropathologica

, Volume 33, Issue 1, pp 1–8 | Cite as

Symmetrical infantile thalamic degeneration with focal cytoplasmic calcification

  • Mary Ambler
  • William O'Neil
Original Investigations

Summary

Infantile thalamic degeneration is a rare clinico-pathological entity. Restricted location of the lesion and peculiar cytopathological changes serve to distinguish this disorder from other common encephalopathies.

Optical and ultrastructural studies demonstrate cytoplasmic calcopherules in previously viable cells.

According to current concepts of acute cellular reactions to injury and mechanism of intracellular calcification, the cytological changes cannot be attributed to either hypoxic ischemic cell change or dystrophic calcification.

By analogy to other human and pathological material, the most likely basis for nondystrophic calcopherule formation is toxic or infectious injury with local synthesis, or autophagic or phagolysosomal degradation of cellular debris of specific chemical composition favoring calcium deposition.

Key words

Thalamus Cytoplasmic calcospherules Non-dystrophic Electron microscopy 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Mary Ambler
    • 1
  • William O'Neil
    • 1
  1. 1.Department of Pathology (Neuropathology) and PediatricsRhode Island HospitalProvidenceUSA

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