Cancer Chemotherapy and Pharmacology

, Volume 29, Issue 4, pp 329–330 | Cite as

Interferon-related cortical blindness

  • Ofer Merimsky
  • Puiu Nisipeanu
  • Anat Loewenstein
  • Irith Reider-Groswasser
  • Samario Chaitchik
Short Communication Alpha-Interferon, Cortical Blindness

Summary

The term cortical blindness indicates loss of sight due to bilateral lesions in the occipital lobes. It is a rare but severe side effect produced by chemotherapeutic agents. Cortical blindness was diagnosed in a 75-year-old man who had been treated with alpha-interferon for metastatic renal-cell carcinoma. The absence of focal neurological signs and of abnormal findings as determined by two repeated computed tomography (CT) scans of the brain, which excluded structural damge to the occipital lobes, suggest that metabolic or toxic reactions may have caused the cortical blindness diagnosed in our patient. The temporal relationship between the treatment with alpha-interferon and the development of cortical blindness indicates that this substance may have been the causative agent for this phenomenon.

References

  1. 1.
    Adams RD, Victor M (1989) Principles of neurology. McGraw Hill, New York, pp 347–617Google Scholar
  2. 2.
    Bergman PS (1957) Cerebral blindness. Arch Neurol Psychiatr 78: 568Google Scholar
  3. 3.
    Berman IJ, Mann MP (1980) Seizures and transient cortical blindness associated withcis-platinum(II) diamminedichloride (PDD) therapy in a thirty-year-old man. Cancer 45: 764Google Scholar
  4. 4.
    Byrd RL, Rohrbaugh TM, Raney RB, Norris DG (1981) Transient cortical blindness secondary to vincristine therapy in childhood malignancies. Cancer 47: 37Google Scholar
  5. 5.
    Diamond SB, Rudolph SH, Lubicz SS, Deppe G, Cohen CJ (1982) Cerebral blindness in association with cisplatinum chemotherapy for advanced carcinoma of the fallopian tube. Obstet Gynecol 59: 84Google Scholar
  6. 6.
    Merimsky O, Reider-Groswasser I, Inbar M, Chaitchik S (1990) Interferon related mental deterioration and behavioural changes in patients with renal cell carcinoma. Eur J Cancer 26: 596Google Scholar
  7. 7.
    Posner JB, Schori M (1980) Cerebrovascular complication of cancer. Clin Bull 10: 158Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Ofer Merimsky
    • 1
  • Puiu Nisipeanu
    • 2
  • Anat Loewenstein
    • 3
  • Irith Reider-Groswasser
    • 4
    • 5
  • Samario Chaitchik
    • 1
  1. 1.Department of OncologyTel-Aviv Medical CenterTel-AvivIsrael
  2. 2.Department of NeurologyTel-Aviv Medical CenterTel-AvivIsrael
  3. 3.Department of OphthalmologyTel-Aviv Medical CenterTel-AvivIsrael
  4. 4.Section of NeuroradiologyTel-Aviv Medical CenterTel-AvivIsrael
  5. 5.Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

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