Skip to main content
SpringerLink
Log in

Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin

  • Review
  • Alkylating Agents, Cisplatin, Chemotherapy, Drug Resistance, ENA Excision Repair
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Andrews P, Murphy M, Howell S (1985) Differential potentiation of alkylating and platinating agents' cytotoxicity in human ovarian carcinoma cells by glutathione depletion. Cancer Res 45:6250

    Google Scholar 

  2. Andrews P, Murphy M, Howell S (1987) Differential sensitization of human ovarian carcinoma and mouse L1210 cells to cisplatin and melphalan by glutathione depletion. Mol Pharmacol 30:643

    Google Scholar 

  3. Andrews P, Schiefer M, Murphy M, Howell S (1988) Enhanced potentiation of cisplatin cytotoxicity in human ovarian carcinoma cells by prolonged glutathione depletion. Chem Biol Interact 65:51

    Google Scholar 

  4. Barrows L, Borchers A, Paxton M (1987) Transfectant CHO cells expressingO6-alkylguanine-DNA-alkyltransferase display increased resistance to DNA damage other thanO6-guanine alkylation. Carcinogenesis 8:1853

    Google Scholar 

  5. Batist G, Torres-Garcia S, Demuys J-M, Greene D, Lehnert M, Rochon M, Panasci L (1989) Enhanced DNA cross-link removal: the apparent mechanism of resistance in a clinically relevant melphalanresistant human breast cancer cell line. Mol Pharmacol 36:224

    Google Scholar 

  6. Bedford P, Fichtinger-Schepman A, Shellard S, Walker M, Masters J, Hill B (1988) Differential repair of DNA adducts in human bladder and testicular tumour continous cell lines. Cancer Res 48:3019

    Google Scholar 

  7. Bodell W, Tokuda K, Ludlum D (1988) Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated withN-(2-chloroethyl)-N-nitrosourea. Cancer Res 48:4489

    Google Scholar 

  8. Bohr V (1991) Gene specific DNA repair. Carcinogenesis 12:1983

    Google Scholar 

  9. Bungo M, Fujiwara Y, Kasahara K, Nakagawa K, Ohe Y, Sasaki Y, Irino S, Saijo N (1990) Decreased accumulation as a mechanism of resistance tocis-diamminedichloroplatinum(II) in human non-small cell lung cancer cell lines: relation to DNA damage and repair. Cancer Res 50:2549

    Google Scholar 

  10. Chabner BA, Myers CE (1989) Clinical pharmacology of cancer chemotherapy. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer, J. B. Lippincott, Philadelphia, p 349

    Google Scholar 

  11. Chao C, Lee Y, Lin-Shao S (1990) Phenotypic reversion of cisplatin resistance in human cells accompanies reduced host cell reactivation of damaged plasmid. Biochem Biophys Res Commun 170:851

    Google Scholar 

  12. Chao C, Huang SLHH, Lin-Shao S (1991) Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA. Mol Cell Biol 11:2075

    Google Scholar 

  13. Chao C, Lee Y, Cheng P, Lin-Shao S (1991) Enhanced host cell reactivation of damaged plasmid DNA in HeLa cells resistant tocis-diamminedichloroplatinum(II). Cancer Res 51:601

    Google Scholar 

  14. Cheng S, Sancar A, Hearst J (1991) RecA-dependent incision of psoralen-crosslinked DNA by (A)BC excinuclease. Nucleic Acids Res 19:657

    Google Scholar 

  15. Chu G, Chang E (1990) Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA. Proc Natl Acad Sci USA 87:3324

    Google Scholar 

  16. Dabholkar M, Eastman A, Reed E (1990) Host-cell reactivation of cisplatin-damaged pRSV cat in human lymphoid cell line. Carcinogenesis 11:1761

    Google Scholar 

  17. De Vries E, Meijer C, Timmer-Bosscha H, Berendsen H, De Leij L, Scheper R, Mulder N (1989) Resistance mechanisms in three human small cell lung cancer cell lines established from one patient during clinical follow-up. Cancer Res 49:4175

    Google Scholar 

  18. Dolan ME, Young GS, Pegg AE (1986) Effect ofO6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to cytotoxic effects of chloroethylating agents. Cancer Res 46:4500

    Google Scholar 

  19. Donahue B, Augot M, Bellon S, Treiber D, Toney J, Lippard S, Essigmann J (1990) Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpC) and d(ApG) DNA adducts of the anticancer drug cisplatin. Biochemistry 29:5872

    Google Scholar 

  20. Dorr RT, Bowdan GT, Alberts DS, Liddil JD (1985) Interaction of mitomycin C with mammalian DNA detected by alkaline elution. Cancer Res 45:3510

    Google Scholar 

  21. Downes C, Mullinger A, Johnson R (1987) Action of etoposide (VP-16-123) on human cells: no evidence for topoisomerase II involvement in excision repair of UV-induced DNA damage, nor for mitochondrial hypersensitivity in ataxia telangiectasia. Carcinogenesis 8:1613

    Google Scholar 

  22. Dresler S, Robinson-Hill R (1987) Direct inhibition of UV-induced DNA excision repair in human cells by novobiocin, coumermycin and nalidixic acid. Carcinogenesis 8:813

    Google Scholar 

  23. Dulhanty A, Li M, Whitmore G (1989) Isolation of Chinese hamster ovary cell mutants deficient in excision repair and mitomycin C bioactivation. Cancer Res 49:117

    Google Scholar 

  24. Dumenco LL, Warman B, Hatzoglou M, Lim IK, Abboud SL, Gerson SL (1989) Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterialO6-guanine-DNA-alkyltransferase. Cancer Res 49:6044

    Google Scholar 

  25. Eastman A (1987) Cross-linking of glutathione to DNA by cancer chemotherapeutic platinum coordination complexes. Chem Biol Interact 61:241

    Google Scholar 

  26. Eastman A, Schulte N (1988) Enhanced DNA repair as a mechanism of resistance tocis-diamminedichloroplatinum(II). Biochemistry 27:4730

    Google Scholar 

  27. Eastman A, Schulte N, Sheibani N, Sorenson C (1988) Mechanisms of resistance to platinum drugs. In: Nicolini M (ed) Platinum and other metal coordination compounds in cancer chemotherapy. Martinus Nijhoff, Boston, p 178

    Google Scholar 

  28. Erickson L, Laurent G, Sharkey N, Kohn K (1980) DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells. Nature 288:727

    Google Scholar 

  29. Friedberg EC (1985) DNA repair: Freeman and Cie, New York

    Google Scholar 

  30. Geleziunas R, McQuillan A, Malapetsa A, Hutchinson M, Kopriva D, Wainberg M, Hiscott J, Bramson J, Panasci L (1991) Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards. J Natl Cancer Inst 83:557

    Google Scholar 

  31. Gonzaga P, Harris L, Margison G, Brent T (1990) Evidence that covalent complex formation between BCNU-treated oligonucleotides andE. coli alkyltransferases requires theO6-alkylguanine function. Nucleic Acids Res 18:3961

    Google Scholar 

  32. Hamilton T, Winker M, Louie K, Batist G, Behrens B, Tsuruo T, Grotzinger K, McCoy W, Young R, Ozols R (1985) Augmentation of Adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion. Biochem Pharmacol 34:2583

    Google Scholar 

  33. Hansson J, Wood R (1989) Repair synthesis by human cell extracts in DNA damaged bycis- andtrans-diamminedichloroplatinum(II). Nucleic Acids Res 20:8073

    Google Scholar 

  34. Hansson J, Munn M, Dean Rupp W, Kahn R, Wood R (1989) Localization of DNA repair synthesis by human cell extracts to a short region at the site of a lesion. J Biol Chem 264:21 788

    Google Scholar 

  35. Hoban P, Walton M, Robson C, Godden J, Stratford I, Workman P, Harris A, Hickson I (1990) Decreased NADPH: cytochrome P-450 reductase activity in impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions. Cancer Res 50:4692

    Google Scholar 

  36. Hoeijmakers JHJ, Bootsma D (1990) Molecular genetics of eukaryotic DNA excision repair. Cancer Cells 2:311

    Google Scholar 

  37. Ishida R, Buchwald M (1982) Susceptibility of Fanconi's anemia lymphoblasts to DNA cross-linking and alkylating agents. Cancer Res 42:4000

    Google Scholar 

  38. Jennerwein M, Eastman A, Kokhar A (1991) The role of DNA repair in resistance of L1210 cells to isomeric 1,2-diamminocyclohexaneplatinum complexes and ultraviolet irradiation. Mutat Res 254:89

    Google Scholar 

  39. Jiang B, Bank B, Hsiang Y, Shen T, Potmesil M, Silber R (1989) Lack of drug induced DNA cross-links in chlorambucil-resistant Chinese hamster ovary cells. Cancer Res 49:5514

    Google Scholar 

  40. Johnson NP, Butour JL, Villani G, Wimmer FM, Defais M, Pierson V, Brabec V (1989) Metal antitumor compounds: the mechanism of action of platinum complexes. Progress in Clinical Biochemical Medicine.

  41. Knox R, Lydall D, Friedlos F, Basham C, Roberts J (1987) The effect of monofunctional or difunctional platinum adducts and of various other associated DNA damage on the expression of transfected DNA in mammalian cell lines sensitive or resistant to difunctional agents. Biochim Biophys Acta 908:214

    Google Scholar 

  42. Kuroda H, Sugimoto T, Ueda K, Tsuchida S, Horii Y, Inazawa J, Sato K, Sawada T (1991) Different drug sensitivity in two neuroblastoma cell lines established from the same patient before and after chemotherapy. Int J Cancer 47:732

    Google Scholar 

  43. Lindhal T, Sedgwick B (1988) Regulation and expression of the adaptive response to alkylating agents. Annu Rev Biochem 55:133

    Google Scholar 

  44. Litterst C, Bertolero F, Uozumi J (1985) The role of glutathione and metallothionein in the toxicity and subcellular binding of cisplatin. In: McBrien D, Slater T (eds). Biochemical mechanisms of platinum antitumour drugs. IRL, Oxford, p 227

    Google Scholar 

  45. Long B, Newhouse L, Brattain M (1987) Characterization of acquired resistance to etoposide (VP16) and teniposide (VM26). Proc Am Assoc Cancer Res 28:286

    Google Scholar 

  46. Masuda H, Ozols R, Lai J, Fojo A, Rothenberg M, Hamilton T (1988) Increased DNA repair as a mechanism of acquired resistance tocis-diamminedichloroplatinum(II) in human ovarian cancer cell lines. Cancer Res 48:5713

    Google Scholar 

  47. Metcalfe S, Cain K, Hill B (1986) Possible mechanism for difference in sensitivity to cis-platinum in human prostate tumor cell lines. Cancer Lett 31:163

    Google Scholar 

  48. Meyn R, Jenkins S, Thompson L (1982) Defective removal of DNA cross-links in a repair deficient mutant of Chinese hamster ovary cells. Cancer Res 42:3106

    Google Scholar 

  49. Micetich K, Zwelling L, Kohn K (1983) Quenching of DNA: platinum(II) monoadducts as a possible mechanism of resistance tocis-diamminedichloroplatinum(II) in L1210 cells. Cancer Res 43:3609

    Google Scholar 

  50. Parker R, Eastman A, Bostick-Bruton F, Reed E (1991) Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation. J Clin Invest 87:772

    Google Scholar 

  51. Pegg AE (1990) MammalianO6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 50:6119

    Google Scholar 

  52. Pinto A, Lippard S (1985) Binding of the antitumor drugcis-diamminedichloroplatinum(II) (cisplatin) to DNA. Biochim Biophys Acta 780:167

    Google Scholar 

  53. Plooy A, Van Dijk M, Berends F, Lohman P (1985) Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated withcis-diamminedichloroplatinum(II). Cancer Res 45:4178

    Google Scholar 

  54. Rawlings C, Roberts J (1986) Walker rat carcinoma cells are exceptionally sensitive tocis-diamminedichloroplatinum(II) (cisplatin) and other difunctional agents but not defective in the removal of platinum-DNA adducts. Mutat Res 166:157

    Google Scholar 

  55. Reardon J, Spielmann P, Huang J, Sastry S, Sancar A, Hearst J (1991) Removal of psoralen monoadducts and crosslinks by human cell free extracts. Nucleic Acids Res 19:4623

    Google Scholar 

  56. Richon VM, Schulte N, Eastman A (1987) Multiple mechanisms of resistance tocis-diamminedichloroplatinum(II) in murine leukemia L1210 cells. Cancer Res 47:2056

    Google Scholar 

  57. Roberts J, Friedlos F, Scott D, Ormerod M, Rawlings C (1986) The unique sensitivity of Walker rat tumor cells to difunctional agents is associated with a failure to recover from inhibition of DNA synthesis and increased chromosome damage. Mutat Res 166:169

    Google Scholar 

  58. Robins P, Harris A, Goldsmith I, Lindhal T (1983) Cross-linking of DNA induced by chloroethylnitrosourea is prevented byO 6-methylguanine-DNA methyltransferase. Nucleic Acids Res 11:7743

    Google Scholar 

  59. Robins P, Jones C, Biggerstaff M, Lindhal T, Wood R (1991) Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA. EMBO J 10:3913

    Google Scholar 

  60. Sheibani N, Jennerwein M, Eastman A (1989) DNA repair in cells sensitive and resistant tocis-diamminedichloroplatinum(II): host cell reactivation of damaged plasmid DNA. Biochemistry 28:3120

    Google Scholar 

  61. Singer B (1975) The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis. Prog Nucleic Acid Res Mol Biol 15:219

    Google Scholar 

  62. Sorenson C, Eastman A (1988) Influence ofcis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells. Cancer Res 48:6703

    Google Scholar 

  63. Tan K, Per S, Boyce R, Mirabelli C, Croolie S (1988) Altered expression and transcription of the topoisomerase II gene in nitrogen mustard-resistant human cells. Biochem Pharmacol 37:4413

    Google Scholar 

  64. Teicher B, Hoden S, Kellet M, Shea T, Cucchi C, Rosowsky A, Henner W, Frei E III (1987) Characterization of a human squamous carcinoma cell line resistant tocis-diamminedichloroplatinum(II). Cancer Res 47:388

    Google Scholar 

  65. Ullah S, Husain I, Carlton W, Sancar A (1989) Human nucleotide excision repair in vitro: repair of pyrimidine dimers, psoralen and cisplatin adducts by HeLa cell-free extract. Nucleic Acids Res 17:4471

    Google Scholar 

  66. Van Houten B (1990) Nucleotide excision repair inEscherichia coli. Microbiol Rev 54:18

    Google Scholar 

  67. Waldstein E, Cao E, Miller M, Cronkite E, Setlow R (1982) Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity forO6-methylguanine. Proc Natl Acad Sci USA 79:4786

    Google Scholar 

  68. Walker G (1987) The SOS response ofEscherichia coli. In: Neidhardt FC (ed)Escherichia coli andSalmonella typhimurium. ASM, Washington, p 1347

    Google Scholar 

  69. Waud W (1987) Differential uptake ofcis-diamminedichloroplatinum(II) by sensitive and resistant murine L1210 leukemia cells. Cancer Res 47:6549

    Google Scholar 

  70. Waxman D (1990) Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy. Cancer Res 50:6449

    Google Scholar 

  71. Wood R, Robins P, Lindhal T (1988) Complementation of xeroderma pigmentosum DNA repair defect in cell-free extracts. Cell 53:97

    Google Scholar 

  72. Yarosh D, Barnes D, Erickson L (1986) Transfection of DNA from a chloroethylnitrosourea-resistant tumor cell line (Mer+) to a sensitive tumor cell line (Mer−) results in a tumor cell line resistant to MNNG and CNU that has increasedO6-methylguanine-DNA-methyltransferase levels and reduced levels of DNA interstrand cross-linking. Carcinogenesis 7:1603

    Google Scholar 

  73. Zwelling L, Anderson T, Kohn K (1979) DNA protein and DNA interstrand cross-linking bycis- andtrans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity. Cancer Res 39:365

    Google Scholar 

  74. Zwelling L, Michaels S, Schwartz H, Dobson P, Kohn K (1981) DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia tocis-diamminedichloroplatinum(II) andL-phenylalanine mustard. Cancer Res 41:640

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Pharmacologie et Toxicologie Fondamentales du CNRS, 205 route de Narbonne, F-31077, Toulouse Cedex, France

    P. Calsou & B. Salles

Authors
  1. P. Calsou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Salles
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Calsou, P., Salles, B. Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin. Cancer Chemother. Pharmacol. 32, 85–89 (1993). https://doi.org/10.1007/BF00685607

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00685607

Keywords

Search

Navigation