Cancer Chemotherapy and Pharmacology

, Volume 28, Issue 4, pp 298–301 | Cite as

The stability of mesna in beverages and syrup for oral administration

  • Marshall P. Goren
  • Beverly A. Lyman
  • Jackie T. Li
Original Articles Drug Stability, Ifosfamide, Oral Mesna
  • 80 Downloads

Summary

We evaluated the stability of the aqueous formulation of mesna during storage in syringes and after dilution in beverages and syrups. Measurements of the concentrations of mesna showed that the undiluted formulation was stable for at least 9 days in standard polypropylene syringes at 5°, 24°, and 35°C. There was no detectable oxidation of mesna to dimesna over the course of at least 1 week when mesna was diluted 1:2 and 1:5 in syrups and incubated at 24°C in capped tubes. Concentration changes were clinically negligible for 1:2, 1:10, and 1:100 dilutions of mesna in six carbonated drinks, two juices, and milk after incubation for 24 h at 5°C. Thus, the aqueous mesna formulation is stable when diluted and stored in a variety of beverages and syrups under conditions suitable for oral administration.

Keywords

Cancer Research Syringe Oral Administration Polypropylene Concentration Change 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Marshall P. Goren
    • 1
    • 2
  • Beverly A. Lyman
    • 3
  • Jackie T. Li
    • 1
  1. 1.Department of Pathology and Laboratory MedicineSt. Jude Children's Research HospitalMemphisUSA
  2. 2.Department of PathologyUniversity of Tennessee-MemphisUSA
  3. 3.Department of Clinical Laboratory SciencesUniversity of Tennessee-MemphisUSA

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