Summary
In an ongoing phase II trial conducted in advanced breast cancer, we tested a therapy schedule consisting of continuous, 24-h infusion of 5 g/m2 ifosfamide (IFO) in 3 l dextrose saline with mesna (MSN), repeated every 3 weeks until disease progression. Since September 1988, 16 heavily pretreated patients with advanced disease (11 with visceral lesions) considered refractory to standard chemotherapy (regimens always including cyclophosphamide) have been included. Objective partial remissions were observed in two cases (one in liver and one in soft-tissue and pleural lesions), and disease stabilization for at least 3 months occurred in four cases. No treatment-related death was recorded and tolerance was judged to be excellent (six cases) or acceptable in all instances. The haematological toxicity consisted mainly of transient leucopenia (nadirs evaluated by WHO scale as grade 3 in 43% and grade 4 in 29%), sometimes associated with thrombocytopenia (grade 3 in 7% and grade 4 in 7%). Other side effects included nausea and/or vomiting (grade 3-4 in 33%); worsening of preexisting alopecia (five cases); haemorrhagic cystitis (one case); mild, transient somnolence (two cases); and moderate fluid retention (two cases). We concluded that infusion of 5 g/m2 IFO over 24 h with MSN rescue might represent an acceptable second-or third-line salvage regimen. Close monitoring of haematological and renal function parameters is recommended. A larger number of patients will be treated in a continuation of this study to evaluate the true response rate within narrower confidence limits.
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References
Andriole GL, Sandlung J, Miser J, Arasi V, Linehan M, Magrath I (1987) The efficacy of mesna (2-mercaptoethane sodium sulfonate) as a uroprotectant in patients with hemorrhagic cystitis receiving further oxazaphosphorine chemotherapy. J Clin Oncol 5: 799
Brade WP, Herdrich K, Varini M (1985) Ifosfamide—pharmacology, safety and therapeutic potential. Cancer Treat Rev 12: 1
Bramwell V, Mouridsen HT, Santoro A, Blackledge G, Somers R, Verwey J, Dombernowsky P, Onsrud M, Thomas D, Sylvester R, Van Oosterom AT (EORTC Soft-tissue and Bone Sarcoma Group) (1987) Cyclophosphamide versus ifosfamide: final report of a randomized phase II trial in adult soft-tissue sarcomas. Eur J Cancer Clin Oncol 23: 311
Hayward JL, Carbone PP, Heuson JC, Kumaoka S, Segaloff A, Rubens RD (1977) Assessment of response in advanced breast cancer. Eur J Cancer 13: 89
Loehrer PJ (ed) (1989) Current developments and future direction with ifosfamide. Semin Oncol 16 (1) [Suppl 3]
Meanwell C, Blake A, Kelly K, Honigsberger L, Blackledge G (1986) Prediction of ifosfamide/mesna associated encephalopathy. Eur J Cancer Clin Oncol 22: 815
Steger G, Dittrich C, Schlappack O, Mader R, Herold C, Brade W, Keller A, Moser K (1988) Toxicity and response to high-dose ifosfamide/mesna as salvage therapy of advanced breast cancer. J Cancer Res Clin Oncol 114: 602
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Paridaens, R., Focan, C., Michel, J. et al. Experience of the Belgian Society of Medical Oncology with single-administration 5 g/m2 ifosfamide with mesna as second- or third-line therapy in advanced breast cancer. Cancer Chemother. Pharmacol. 26 (Suppl 1), S63–S65 (1990). https://doi.org/10.1007/BF00685423
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DOI: https://doi.org/10.1007/BF00685423