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Acta Neuropathologica

, Volume 57, Issue 2–3, pp 81–84 | Cite as

Pituitary adenoma with amyloid deposits and hyperprolactinemia

Case report and review
  • P. Delafontaine
  • F. Ochsner
  • G. P. Pizzolato
Original Works

Summary

Amyloid deposits were observed in a prolactinoma accompanying an amenorrhea-galactorrhea syndrome. The amyloid showed typical fibrils that were grouped in compact bundles. The seven other cases described in the literature are reviewed; evidence is accumulating that this amyloid can be secreted by epithelial cells.

Key words

Pituitary adenoma Amyloid 

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References

  1. 1.
    Barr R, Lampert P (1972) Intrasellar amyloid tumor. Acta Neuropathol (Berl) 21:83–86Google Scholar
  2. 2.
    Bilbao J, Horvath E, Hudson AR, Kovacs K (1975) Pituitary adenoma producing amyloid-like substance. Arch Pathol 99:411–415Google Scholar
  3. 3.
    Bilbao J, Kovacs K, Horvath E, Higgins HP, Horsey WJ (1975) Pituitary melanocorticotrophinoma with amyloid deposition. Can J Neurol Sci 2:199–202Google Scholar
  4. 4.
    Glenner GG (1980) Amyloid deposits and amyloidosis. The β-fibrilloses. N Engl J Med 302:1283–1292, 1333–1343Google Scholar
  5. 5.
    Hastrup J (1966) Chromophobe adenoma of the pituitary with extensive calcifications. Acta Neuropathol (Berl) 6:98–100Google Scholar
  6. 6.
    Kraus EJ (1924) Zur Pathogenese der Dystrophia adiposogenitalis. Med Klin 37:1290–1292Google Scholar
  7. 7.
    Pages A, Marty-Double CH (1977) In: Histopathologie endocrinienne. Masson, Paris, pp 14–22Google Scholar
  8. 8.
    Pearse AGE, Ewen SWB, Polak JM (1972) The genesis of apudamyloid in endocrine polypeptide tumours: Histochemical distinction from immunoamyloid. Virchows Arch B [Cell Pathol] 10:93–107Google Scholar
  9. 9.
    Ribbert H (1882) Ein Tumor der Hypophysis. Virchows Arch A Pathol Anat 90:539–541Google Scholar
  10. 10.
    Russell DS, Rubinstein LJ (1971) In: Pathology of tumours of the nervous system, 3rd edn. Arnold, London, pp 234–237Google Scholar
  11. 11.
    Schober R, Nelson D (1975) Fine structure and origin of amyloid deposits in pituitary adenoma. Arch Pathol 99:403–410Google Scholar
  12. 12.
    Westermark P, Grimelius L, Polak JM, Larsson LI, van Noorden S, Wilander E, Pearse AGE (1977) Amyloid in polypeptide hormone-producing tumors. Lab Invest 37:212–215Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • P. Delafontaine
    • 1
  • F. Ochsner
    • 1
  • G. P. Pizzolato
    • 1
  1. 1.Institut de Pathologie, Division de Neuropathologie, Hôpital CantonalUniversité de GenèveGenèveSwitzerland

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