Acta Neuropathologica

, Volume 36, Issue 3, pp 259–267 | Cite as

Immunoperoxidase staining of simple nuclear bodies in subacute sclerosing panencephalitis (SSPE) by antiserum to measles nucleocapsids

  • Hannah R. Brown
  • Halldor Thormar
Original Investigations


Nuclear bodies have been found with great consistency in brain tissue from patients with subacute sclerosing panencephalitis (SSPE). There has been controversy as to the significance of these structures and their relationship, if any, to the disease. In this study, a non-productive, cell-associated strain of SSPE measles virus grown in tissue culture on Vero cells showed the continued presence of nuclear bodies, frequently in close association with the SSPE measles virus nucleocapsids. Immunoperoxidase (I-P) staining with specific antiserum against measles virus nucleocapsids was done. The resultant positive labeling of the nuclear bodies demonstrates that they contain measles virus antigen and suggests that the nuclear bodies play a role in the development of the measles virus nucleocapsids of SSPE.

Key words

Subacute sclerosing panencephalitis Nuclear bodies Nucleocapsids Immunoperoxidase 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Hannah R. Brown
    • 1
  • Halldor Thormar
    • 1
  1. 1.N. Y. S. Institute for Basic Research in Mental RetardationStaten IslandUSA

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