Acta Neuropathologica

, Volume 60, Issue 1–2, pp 149–152 | Cite as

Adrenoleukodystrophy-cerebello-brainstem dominant case

  • S. Kuroda
  • A. Hirano
  • S. Yuasa
Short Original Communications


A case of adrenoleukodystrophy was studied morphologically and biochemically. The patient was a 28-year-old man with no family history of adrenoleukodystrophy. His neurologic symptoms were cerebellar ataxia, spastic paraplegia, pseudo-bulbar palsy, and a minimal visual disturbance, with neither adrenal nor hypogonadal symptoms.

The morphological and biochemical findings in this case are identical with those in typical adrenoleukodystrophy, but the topographical distribution of the lesions is distinctly different. The changes selectively affect the white matter in the cerebellum and brain stem in contrast to minimal involvement of the occipital white matter.

Key words

Adrenoleukodystrophy Cerebello-brainstem involvement Electron microscopy Biochemistry 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • S. Kuroda
    • 1
  • A. Hirano
    • 2
  • S. Yuasa
    • 3
  1. 1.Department of NeuropsychiatryOkayama University Medical SchoolOkayamaJapan
  2. 2.Division of Neuropathology, Department of Pathology, Montefiore Medical CenterAlbert Einstein College of MedicineBronxUSA
  3. 3.Department of BiochemistryOkayama University Medical SchoolOkayamaJapan

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