Acta Neuropathologica

, Volume 30, Issue 1, pp 43–50 | Cite as

The pathology of the human muscle spindle

A light microscopic, biometric and histochemical study
  • J. De Reuck
Original Investigations

Summary

A biometric study was made on 810 muscle spindles in 214 muscles. The absence of atrophy of the intra-fusal muscle fibres and the frequency of spindles with focal dilatation of the periaxial space were the prominent features in denervated muscles. Thickening of the spindle capsule without atrophy of the intra-fusal muscle fibres was often seen in dystrophic muscles. The frequency of changes was greatest in cases of myositis. Eleven spindles were studied by histochemical techniques. In one case of denervation atrophy, all the intrafusal muscle fibres had an enzyme pattern similar to the grouping that occurs in extra-fusal fibres during reinnervation. The outer membranes of the thickened spindle capsule, frequent in dystrophic muscles, were 5-Nucleotidase rich an ATPase poor. The inner membrane was ATPase rich and 5-Nucleotidase poor.

The pathology of the muscle spindle is less atypical than previous studies suggest.

Key words

Muscle Spindle Denervation Atrophy Muscular Dystrophy Myositis Biometric Analysis Histochemistry 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, R. D., Denny-Brown, D., Pearson, C. M.: Diseases of muscle a study of pathology, 2nd Ed. New York: Hoeber 1962Google Scholar
  2. Barka, T., Anderson, P. J.: Histochemistry. New York: Hoeber 1965Google Scholar
  3. Beckett, E. B., Bourne, G. H.: Some histochemical observations on human dystrophic muscle. Science126, 357 (1957)Google Scholar
  4. Brzin, M., Tennyson, V., Duffy, D.: Acetylcholinesterase in frog sympathetic and dorsal root ganglia. J. Cell Biol.31, 215–242 (1966)Google Scholar
  5. Cazzato, G., Walton, J.: The pathology of the muscle spindle: a study of biopsy material in various muscular and neuromuscular diseases. J. neurol. Sci.7, 15–70 (1968)Google Scholar
  6. Cooper, S., Daniel, P. M.: Muscle spindles in man: their morphology in the lumbricals and the deep muscles of the neck. Brain86, 563–594 (1963)Google Scholar
  7. De Reuck, J., Ansari, K.: A technique of comparison of muscle fibre size distribution in human skeletal muscles. Medikon7, 311–313 (1973)Google Scholar
  8. De Reuck, J., Vander Eecken, H., Roels, H.: Biometrical and histochemical comparison between extra-fusal and intra-fusal muscle fibres in denervated and re-innervated rat muscle. Acta neuropath. (Berl.)25, 249–258 (1973)Google Scholar
  9. De Reuck, J.: Biometric analyses of spindles in normal human skeletal muscles. Acta neurol. belg.73, 339–347 (1973)Google Scholar
  10. Dubowitz, V.: Histochemical aspects of muscle disease. In: Disorders of voluntary muscle, pp. 239–276. Ed. J. Walton. London- Churchill 1969Google Scholar
  11. Gömori, G.: A improved histochemical technic for phosphatase. Stain Technol.25, 81 (1950)Google Scholar
  12. Grüner, E.: La structure fine du fuseau neuromusculaire humain. Rev. neurol.104, 490–507 (1961)Google Scholar
  13. Kennedy, W. R.: Innervation of normal human muscle spindles Neurology (Minneap.)20, 463–475 (1970)Google Scholar
  14. Kennedy, W. R.: Innervation of muscle spindles in amyotrophic lateral sclerosis. Proc. Mayo Clin.46, 245–257 (1971)Google Scholar
  15. Lapresle, J., Milhaud, M.: Pathology du fuseau neuro-musculaire. Rev. neurol.110, 97–122 (1964)Google Scholar
  16. Mair, W. G. P., Tomé, F. M. S.: Atlas of the ultrastructure of diseased human muscle. Edinburgh: Churchill 1972Google Scholar
  17. Margreth, A., Salvati, G.: Biochemical changes in slow muscle by re-innervation with fast nerve fibres. In: Clinical studies in myology. pp. 337–345. Ed. B. A. Kakulas. Amsterdam: Excerpta Medica 1973Google Scholar
  18. Moore, M. J., Rebeiz, J. J., Holden, M., Adams, R. D.: Biometric analyses of normal skeletal muscle. Acta neuropath. (Berl.)19, 51–69 (1971)Google Scholar
  19. Olkowski, Z., Manocha, S. L.: Muscle Spindle: In: The structure and function of muscle, vol. II, pp. 366–482 Ed. G. H. Bourne. New York: Academic Press 1973Google Scholar
  20. Patel, A. N., Lalitha, V. S., Dastur, D. K.: The spindle in normal and pathological muscle: an assessment of the histological changes. Brain91, 737–750 (1968)Google Scholar
  21. Pearse, E.: Histochemistry: theoretical and applied, p. 910. London: Churchill 1960Google Scholar
  22. Romanul, F. C., Van der Meulen, J. P.: Slow and fast muscles after cross-innervation: enzymatic and physiological changes. Arch. Neurol. (Chic.)17, 387–402 (1967)Google Scholar
  23. Saghal, V., Nayyar, R., Betts, H. B.: Histochemical profile of human intra-fusal fibres. In: Basic research in myology, pp. 41–48. Ed. B. A. Kakulas. Amsterdam: Excerpta Medica 1973Google Scholar
  24. Spiro, A., Beilin: Human muscle spindle histochemistry. Arch. Neurol. (Chic.)20, 271–274 (1969)Google Scholar
  25. Shantha, T. R., Golarz, M. N., Bourne, G. H.: Histological and histochemical observation on the capsule of the muscle spindle in normal and denervated muscle. Acta anat. (Basel)69, 632–646 (1968)Google Scholar
  26. Swash, M., Fox, K. P.: The effect of age on human skeletal muscle. Studies of the morphology and innervation of muscle spindles. J. neurol. Sci.16, 417–432 (1971)Google Scholar
  27. Swash, M.: The morphology and innervation of the muscle spindle in dystrophia myotonia. Brain95, 357–368 (1972)Google Scholar
  28. Swash, M., Fox, K. P.: The pathology of the human muscle spindle: effect of denervation. J. neurol. Sci.22, 1–24 (1974)Google Scholar
  29. Siegel, S.: Non parametric statistics for the behavioral siences: “the Kolmogorov-Smirnov two sample test”, pp. 127–136. New York: McGraw-Hill 1956Google Scholar
  30. Takeuchi, T., Kuriaki, H.: Histochemical detection of phosphorylase in animal tissue. J. Histochem. Cytochem.3, 153 (1955)Google Scholar
  31. Tower, S. S.: Atrophy and degeneration in the muscle spindle. Brain55, 77–90 (1932)Google Scholar
  32. Wachstein, M., Meisel, E.: Histochemistry of hepatic phosphatase at a physiological Ph. Amer. J. clin. Path.27, 13 (1957)Google Scholar
  33. Wohlfahrt, S.: Muscular atrophy in the diseases of the lower motor neuron. Arch. Neurol. Psychiat. (Chic.)61, 599 (1949)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. De Reuck
    • 1
    • 2
  1. 1.Department of NeurologyUniversity of GhentGentBelgium
  2. 2.Department of PathologyUniversity of GhentBelgium

Personalised recommendations