Summary
The chromosomes of an established human glioma cell line were studied with G-band technique. The cell line had a hypotriploid mode, S=60−61, and there were 10 different marker types in the stemline karyotypes. The origin of most markers could be traced; C and D chromosomes were found to participate in the formation of at least eight markers. The findings in the present material, combined with the observations in a previously studied glioma cell line, indicated a preferential pattern of variation in chromosome groups C and D.
Zusammenfassung
Die Chromosomen einer humanen Gliomazellkultur wurden mit der G-Bandungstechnik untersucht. Die Kultur hatte eine hypotriploide Stammlinie (S=60−61) mit zehn verschiedenen Marker-Chromosomen im Stammliniekaryotypen. Der Ursprung der Mehrzahl der Marker-Chromosomen konnte festgestellt werden; die Chromosomen der Gruppe C und D hatten bei mindestens acht Markers an deren Bildung teilgenommen. Die vorliegende und eine frühere Untersuchung von Gliomakulturen deuten darauf hin, daß spezielle Chromosomen der Gruppen C und D an der Entwicklung des Stammliniekaryotypen dieser Tumoren beteiligt sind.
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Mark, J., Pontén, J. & Westermark, B. Origin of the marker chromosomes in an established hypotriploid glioma cell line studied with G-band technique. Acta Neuropathol 29, 223–228 (1974). https://doi.org/10.1007/BF00685257
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DOI: https://doi.org/10.1007/BF00685257