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Acta Neuropathologica

, Volume 29, Issue 3, pp 223–228 | Cite as

Origin of the marker chromosomes in an established hypotriploid glioma cell line studied with G-band technique

  • Joachim Mark
  • Jan Pontén
  • Bengt Westermark
Original Investigations

Summary

The chromosomes of an established human glioma cell line were studied with G-band technique. The cell line had a hypotriploid mode, S=60−61, and there were 10 different marker types in the stemline karyotypes. The origin of most markers could be traced; C and D chromosomes were found to participate in the formation of at least eight markers. The findings in the present material, combined with the observations in a previously studied glioma cell line, indicated a preferential pattern of variation in chromosome groups C and D.

Key words

Glioma Cell Line Chromosome Analysis G-Band Technique 

Zusammenfassung

Die Chromosomen einer humanen Gliomazellkultur wurden mit der G-Bandungstechnik untersucht. Die Kultur hatte eine hypotriploide Stammlinie (S=60−61) mit zehn verschiedenen Marker-Chromosomen im Stammliniekaryotypen. Der Ursprung der Mehrzahl der Marker-Chromosomen konnte festgestellt werden; die Chromosomen der Gruppe C und D hatten bei mindestens acht Markers an deren Bildung teilgenommen. Die vorliegende und eine frühere Untersuchung von Gliomakulturen deuten darauf hin, daß spezielle Chromosomen der Gruppen C und D an der Entwicklung des Stammliniekaryotypen dieser Tumoren beteiligt sind.

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References

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Joachim Mark
    • 1
  • Jan Pontén
    • 2
  • Bengt Westermark
    • 2
  1. 1.Department of PathologyCentral Hospital of SkövdeSkövdeSweden
  2. 2.The Wallenberg LaboratoryUppsalaSweden

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