Cancer Chemotherapy and Pharmacology

, Volume 27, Issue 6, pp 477–480 | Cite as

Prednimustine combined with mitoxantrone and 5-fluorouracil for first and second-line chemotherapy in advanced breast cancer

  • Hellmut Samonigg
  • Herbert Stöger
  • Anne-Katrin Kasparek
  • Marianne Schmid
  • Johann Dusleag
  • Karl Pfeiffer
  • Michael Smola
  • Peter Steindorfer
  • Peter Lechner
Original Articles Prednimustine, Mitoxantrone, 5-Fluorouracil, Chemotherapy, Advanced Breast Cancer


A total of 60 patients with advanced breast cancer were treated with a combination of prednimustine (P: 110 mg/m2, days 1–5), mitoxantrone (M: 12 mg/m2, day 1) and 5-fluorouracil (F: 500 mg/m2, day 1) (PMF). Treatment was repeated every 3 weeks. In all 53 patients were evaluable for response. A total of 12 subjects had failed prior chemotherapy for metastatic disease. In response to PMF treatment we observed 21 partial remissions and 3 complete remissions, amounting to a total response rate of 45%. The median duration of response was 39 weeks, and median survival was 56 weeks. Doselimiting side effects were leukopenia (40 cases) and thrombocytopenia (11 patients). Nausea and vomiting was experienced by 93% of subjects; in 56% of cases it reached WHO stage II–III. Alopecia occured in 18% of our patients. Our results suggest that PMF represents an active regimen in the treatment of advanced breast cancer and yields a response rate of 45%. Considering that the majority of our patients had not received prior chemotherapy, the question remains open as to whether a 45% response rate outweighs the observed toxicity.


Breast Cancer Cancer Research Median Survival Thrombocytopenia Metastatic Disease 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Hellmut Samonigg
    • 1
  • Herbert Stöger
    • 1
  • Anne-Katrin Kasparek
    • 1
  • Marianne Schmid
    • 1
  • Johann Dusleag
    • 1
  • Karl Pfeiffer
    • 2
  • Michael Smola
    • 3
  • Peter Steindorfer
    • 3
  • Peter Lechner
    • 4
  1. 1.Department of Internal MedicineKarl Franzens-University at GrazGrazAustria
  2. 2.Department of PhysiologyKarl Franzens-University at GrazGrazAustria
  3. 3.Department of SurgeryKarl Franzens-University at GrazGrazAustria
  4. 4.Second Department of SurgeryLandeskrankenhaus GrazGrazAustria

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