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Cancer Chemotherapy and Pharmacology

, Volume 31, Issue 2, pp 123–126 | Cite as

The importance of schedule on diethyldithiocarbamate modulation of drug-induced myelosuppression

  • Christopher J. East
  • Richard F. Borch
Original Articles Myelosuppression, Diethyldithiocarbamate

Summary

Sodium diethyldithiocarbamate (DDTC) has been investigated as a biochemical modulator of the toxicity associated with clinically used cancer chemotherapeutic agents. In the present study, we assessed the ability of DDTC to accelerate recovery of the granulocyte/macrophage progenitor cel (GM-CFC) population following treatment with the myelosuppressive drugs carboplatin (CBDCA), tetrachloro(d,l-trans)1,2-diaminocyclohexane platinum(IV) (tetraplatin), 5-fluorouracil (5-FU), and etoposide (VP-16) in B6D2F1 mice. Myelotoxicity was assessed 24 h after the injection of the anticancer drug using a GM-CFC clonogenic assay. In the case of all four anticancer drugs, the timing of DDTC administration appeared to be a critical parameter with regard to protection. A delay time of 1 h between the injection of the myelotoxic drug and treatment with DDTC (30 mg/kg) resulted in a significant reduction in cytotoxicity to GM-CFC, whereas a longer delay time did not. These results suggest that the timing of DDTC administration may be essential in modulating the myelosuppression associated with many chemotherapeutic regimens used in the clinic.

Keywords

Delay Time Etoposide Carboplatin Chemotherapeutic Agent Anticancer Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DDTC

sodium diethyldithiocarbamate

cDDP

cis-diamminedichloroplatinum

CBDCA

diammine(1,1-cyclobutanedicarboxylato)platinum(II)

tetraplatin

tetrachloro(d,l-trans)1,2-diaminocyclohexane platinum(IV)

GM-CFC

granulocyte/macrophage colony-froming unit

α-MEM

α-minimum essential medium

PWM-SCCM

pokeweed mitogen-stimulated spleen-cell conditioned medium

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Christopher J. East
    • 1
  • Richard F. Borch
    • 1
  1. 1.Department of Pharmacology and Cancer CenterUniversity of Rochester School of Medicine and DentistryRochesterUSA

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