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Protection from ifosfamide-induced alopecia by topical thiols in young rats

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Summary

An animal model for testing substances that might prevent alopecia induced by oxazaphosphorines has been developed. It is based on the fact that the rat pups experience virtually total hair loss following administration of oxazaphosphorines. Using this model, we showed that epicutaneous treatment with sodium thioglycollate prevented ifosfamide-induced hair loss on the treated area. These experiments indicate that prevention of oxazaphosphorine-induced alopecia in man may be achieved by topical thiols.

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References

  1. Connors TA (1966) Protection against the toxicity of alkylating agents by thiols: The mechanism of protection and its relevance to cancer chemotherapy. Eur J Cancer 2:293

    Google Scholar 

  2. Garattini S, Palma V, Reyers-Degli Innocenti I, Guaitani A (1966) Effects of radioprotectors on damage induced by alkylating agents on tumoural and normal tissues. Eur J Cancer 2:237

    Google Scholar 

  3. Hill DL (1975) A review of cyclophosphamide. C. Thomas, Springfield, Illinois, p 176

    Google Scholar 

  4. Ishidate M, Sakurai Y, Yoshida T, Satoh H, Matsui E, Imamura H (1953) Studies on the toxicity of “Nitromin”. Interference of cysteine upon “Nitromin” toxicity. Jpn J Cancer Res 44:386

    Google Scholar 

  5. Powis G, Kooistra KL (1987) Doxorubicin-induced hair loss in the Angora rabbit: a study of treatment to protect against hair loss. Cancer Chemother Pharmacol 20:291

    Google Scholar 

  6. Seipp CA (1985) Adverse of treatment — hair loss. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer, principles and practice of oncology 2nd edn. Lippincot, Philadelphia, p 2007

    Google Scholar 

  7. Stekar J (1973) Teratogenicity of cyclophosphamides in newborn rats. Arzneimittelforschung 23:922

    Google Scholar 

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Authors and Affiliations

  1. Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany

    Jurij Stekar, Peter Hilgard, Wilfried Holtei & Uwe Riemer

Authors
  1. Jurij Stekar
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  2. Peter Hilgard
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  3. Wilfried Holtei
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  4. Uwe Riemer
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Stekar, J., Hilgard, P., Holtei, W. et al. Protection from ifosfamide-induced alopecia by topical thiols in young rats. Cancer Chemother. Pharmacol. 25, 306–307 (1990). https://doi.org/10.1007/BF00684892

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  • DOI: https://doi.org/10.1007/BF00684892

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