Cancer Chemotherapy and Pharmacology

, Volume 25, Issue 4, pp 295–298 | Cite as

Phenotypic variations dictate the intracellular compartmentalization of doxorubicin in normal human bone marrow cells

  • Esther Aghaï
  • Zoltán A. Tökés


In vitro accumulation of doxorubicin in intracellular compartments of normal bone marrow cells was studied with the use of fluorescent microscopy. Both the cytoplasmic and nuclear compartments had distinguishable drug accessibility in the diverse hemopoietic series and in different stages of maturation of each lineage. Nuclei appeared to be more sheltered in the myelogranulogytic series and macrophages appeared to be the least Nuclei of activated phagocytic cells of the myelogranulocytic series and macrophages appeared to be the least accessible to doxorubicin uptake. These observations establish that phenotypic variations dictate the patterns of anthracyclines' subcellular compartmentalization. They also suggest that the molecular mechanism contributing to the intracellular trafficking of doxorubicin deserves more substantial investigation that may contribute to our understanding of drug resistance and sensitity.


Doxorubicin Phenotypic Variation Bone Marrow Cell Anthracyclines Normal Bone 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Esther Aghaï
    • 1
    • 2
  • Zoltán A. Tökés
    • 1
    • 2
  1. 1.Department of Hematology/OncologyChildren's Hospital of Los AngelesLos AngelesUSA
  2. 2.Department of Biochemistry, Comprehensive Cancer Center, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

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