Acta Neuropathologica

, Volume 17, Issue 1, pp 6–13 | Cite as

Experimental organic mercury poisoning—Regeneration of peripheral nerves

  • Taihei Miyakawa
  • Motonori Deshimaru
  • Shiro Sumiyoshi
  • Aoi Teraoka
  • Seijun Tatetsu
Original Investigations

Summary

Rats were given 1 mg of organic mercury compound per rat daily by mouth for 20 days. Peripheral nerves were examined on the 7th day and 250 th day after withdrawal of administration. On the 7th day, mitosis of Schwann cells was observed and on the 250 th day, myelinated fibres were noticeably decreased in numbers, with regeneration of nerve fibres and an increase of collagen in the intercellular spaces. Posterior nerve root ganglion cells were however intact. From this it is speculated that regeneration of injured peripheral nerve fibres, experimentally poisoned with organic mercury, is the result of regeneration of axons growing out to the periphery, and by regeneration of Schwann cells. Regeneration of the peripheral nerves was not however a very marked feature.

Key words

Organic Mercury Compound Peripheral Nerve Regeneration Electron Microscopy 

Zusammenfassung

Ratten wurde oral durch 20 Tage täglich 1 mg organische Quecksilberverbindung verabreicht. Am 7. und 250. Tag nach Ende der Verabreichung wurden die peripheren Nerven untersucht. Am 7. Tag fanden sich Mitosen von Schwannschen Zellen und am 250. Tag deutliche Abnahme der myelinhaltigen Nervenfasern, begleitet von Regeneration der Nervenfasern und Zunahme von Kollagen im intercellulären Raum. Anderseits waren die Ganglienzellen der Hinterwurzeln intakt. Diese Befunde lassen vermuten, daß die Regeneration geschädigter peripherer Nerven nach experimentellen Vergiftung mit organischem Quecksilber durch bis in periphere Abschnitte wachsende Axonsprossen und neugebildete Schwann-Zellen vor sich geht. Die Regenerationstendenz der peripheren Nerven war jedoch im ganzen nicht sehr ausgeprägt.

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Taihei Miyakawa
    • 1
  • Motonori Deshimaru
    • 1
  • Shiro Sumiyoshi
    • 1
  • Aoi Teraoka
    • 1
  • Seijun Tatetsu
    • 1
  1. 1.Department of Neuropsychiatry, Kumamoto UniversitySchool of MedicineKumamotoJapan

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