Acta Neuropathologica

, Volume 34, Issue 2, pp 175–181 | Cite as

The effects of measles virus and various strains of SSPE virus on organotypic cultures of nervous tissue

  • R. D. Sheppard
  • L. A. Feldman
  • L. H. Barbosa
  • C. S. Raine
  • M. B. Bornstein
Short Original Communications


The neurotropic effects, virologic behaviors and morphologic appearances of 4 strains of subacute sclerosing panencephalitis (SSPE) virus have been examined in organotypic cultures of hamster cerebellar tissue and have been compared with the Edmonston strain of measles virus in the same system. While measles virus caused extensive damage to nervous tissue, the SSPE strains, in general, exerted a less deleterious effect. All of the SSPE viruses replicated in this tissue. The SSPE strains showed morphologic variation ranging from normal measles-type virions to apparently nucleocapsid deficient forms. It is speculated that some of these differences between measles and SSPE virus may account for the differences in the in vivo conditions with which they are associated.

Key words

Measles virus Subacute sclerosing panencephalitis Multiple sclerosis Neuroadapted Chronic neurological disorders 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • R. D. Sheppard
    • 1
    • 2
  • L. A. Feldman
    • 3
  • L. H. Barbosa
    • 4
  • C. S. Raine
  • M. B. Bornstein
  1. 1.Saul R. Korey Department of Neurology, Department of Pathology, (Neuropathology)Albert Einstein College of MedicineBronxUSA
  2. 2.Rose F. Kennedy Center for Research in Mental Retardation and Human DevelopmentAlbert Einstein College of MedicineBronx
  3. 3.The Department of MicrobiologyCollege of Medicine and Dentistry of New Jersey New Jersey Medical SchoolNewark
  4. 4.The Infectious Diseases Branch, Collaborative and Field ResearchNational Institute of Neurological Diseases and StrokeBethesda

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