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Synthesis of the C-end of the tetrapeptide gastrin

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Chemistry of Natural Compounds Aims and scope

Conclusions

1. The carbobenzoxy derivative of the C-terminal tetrapeptide of gastrin—the amide of carbobenzoxytryptophanyl-methionylaspartylphenylalanine—has been synthesized by two different routes.

2. In nonnarcotized cats the tetrapeptide obtained causes the secretion of gastric juice with a high content of hydrochloric acid (MR50=11.5 µg/kg).

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Khimiya Prirodnykh Soedinenii, Vol. 5, No. 4, pp. 283–287, 1969

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Atare, Z.A., Vilka, V.S. & Chipens, G.I. Synthesis of the C-end of the tetrapeptide gastrin. Chem Nat Compd 5, 241–243 (1969). https://doi.org/10.1007/BF00683842

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  • DOI: https://doi.org/10.1007/BF00683842

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