Synthesis of the C-end of the tetrapeptide gastrin
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Conclusions
1. The carbobenzoxy derivative of the C-terminal tetrapeptide of gastrin—the amide of carbobenzoxytryptophanyl-methionylaspartylphenylalanine—has been synthesized by two different routes.
2. In nonnarcotized cats the tetrapeptide obtained causes the secretion of gastric juice with a high content of hydrochloric acid (MR50=11.5 µg/kg).
Keywords
Methyl Ester Dipeptide Hydrazide Sodium Bicarbonate Solution Oily ResiduePreview
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References
- 1.R. A. Gregory and J. H. Tracy, Gut,5, 303, 1964; R. A. Gregory, Gastroenterology,51, 953, 1965.CrossRefGoogle Scholar
- 2.J. S. Morley, Nature,204, 933, 1964; H. Gregory, P. M. Hardy, D. S. Jones, G. W. Kenner, and R. C. Sheppard, Nature,204, 931, 1964.CrossRefGoogle Scholar
- 3.J. S. Morley, H. J. Tracy, and R. A. Gregory, Nature,207, 1356, 1965.CrossRefGoogle Scholar
- 4.J. M. Davay, A. H. Land, and J. S. Morley, J. Chem. Soc., C, 555, 1966.Google Scholar
- 5.K. Hofman and W. Hass, J. Am. Chem. Soc.,87, 631, 1965.CrossRefGoogle Scholar
- 6.S. Konturek and M. Grossman, Gastroenterology,50, 650, 1966.PubMedGoogle Scholar
- 7.E. L. Smith, J. Biol. Chem.,175, 39, 1948.PubMedGoogle Scholar
- 8.A. Dekker and S. P. Taylor, J. Biol. Chem.,180, 155, 1949; M. Brenner and R. W. Pfister, Helv. Chim. Acta,34, 2085, 1951.PubMedGoogle Scholar
- 9.E. L. Smith and D. H. Spackman, J. Biol. Chem.,212, 288, 1955.Google Scholar
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