Abstract
The corresponding monophosphates, cyclophosphates, and α, ω-diphosphates were obtained by phosphorylation of 1-(1, 4-dihydroxy-2-pentyl) thymine, 1-(1, 3-dihydroxy-2-propyl) uracil, and their derivatives with selective protection of one of the hydroxyl groups. 2-Cyanoethyl phosphate (CEP) in the presence of N, N′-dicyclohexylcarbodiimide (DCC), polyphosphoric acid, and pyrophosphoryl chloride were used as phosphorylating agents. The dependence of the yields of the products of phosphorylation of 1-(1, 4-dihydroxy-2-pentyl) thymine with CEP on the ratio of the reacting substances and the reaction time was studied. The monophosphates were cyclized under the influence of DCC. In the case of 1-(1, 3-dihydroxy-2-propyl) uracil 1-phosphate a dimeric phosphate was obtained in addition to a cyclophosphate. The acid hydrolysis of the cyclophosphates was investigated.
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See [1] for communication V; see [2] for a preliminary communication.
Deceased.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 678–683, May, 1978.
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Giller, S.A., Sherin', L.A., Zarin', D.É. et al. Analogs of pyrimidine mono- and polynucleotides. Chem Heterocycl Compd 14, 556–561 (1978). https://doi.org/10.1007/BF00673344
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DOI: https://doi.org/10.1007/BF00673344