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Creatinine, urea and uric acid in amniotic fluid, maternal and umbilical cord blood at delivery

Kreatinin, Harnstoff und Harnsäure im Fruchtwasser, mütterlichen Venenblut und Nabelschnurblut zum Zeitpunkt der Geburt

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Summary

Amniotic fluid, maternal vein serum and umbilical cord serum were obtained almost simultaneously from 31 women after an uneventful course of pregnancy. Specimens of amniotic fluid contaminated by blood or meconium were excluded. Creatinine, urea and uric acid were measured by autoanalyser techniques.

The concentrations of creatinine, urea and uric acid in amniotic fluid were significantly higher when compared with the levels in maternal vein serum or umbilical cord serum. Between maternal and umbilical cord serum there were only small or no differences.

The linear correlations of creatinine, urea and uric acid between maternal and umbilical cord serum were greater than those between amniotic fluid and maternal serum or amniotic fluid and cord serum.

It is suggested that the high levels of creatinine, urea and uric acid in amniotic fluid are primarily determined by fetal urine.

Zusammenfassung

In 31 Fällen wurde nach normaler Schwangerschaft parallel Fruchtwasser, mütterliches Venenblut und Nabelschnurblut gewonnen. Fruchtwasserproben, die durch Blut oder Mekonium kontaminiert waren, wurden verworfen. Kreatinin, Harnstoff und Harnsäure wurden mit dem Autoanalyzer bestimmt.

Die Kreatinin-, Harnstoff- und Harnsäurekonzentrationen im Fruchtwasser lagen signifikant höher als die Spiegel im mütterlichen Venenblut- oder Nabelschnurserum. Zwischen mütterlichem Serum und Nabelschnurserum fanden sich geringe oder keine Unterschiede.

Die linearen Korrelationen für Kreatinin, Harnstoff und Harnsäure zwischen mütterlichem Serum und Nabelschnurserum waren größer als die zwischen Fruchtwasser und mütterlichem Serum oder Fruchtwasser und Nabelschnurserum.

Es ist anzunehmen, daß die hohen Kreatinin-, Harnstoff- und Harnsäurespiegel im Fruchtwasser in erster Linie durch den fetalen Urin zustande kommen.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University of Tübingen, West Germany

    M. Anderer & A. E. Schindler

  2. Department of Internal Medicine, University of Tübingen, West Germany

    H. M. Liebich

  3. Universitäts-Frauenklinik, Schleichstr. 4, D-7400, Tübingen, Federal Republic of Germany

    M. Anderer

Authors
  1. M. Anderer
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  2. A. E. Schindler
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  3. H. M. Liebich
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Anderer, M., Schindler, A.E. & Liebich, H.M. Creatinine, urea and uric acid in amniotic fluid, maternal and umbilical cord blood at delivery. Arch. Gynak. 220, 65–72 (1975). https://doi.org/10.1007/BF00673149

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  • DOI: https://doi.org/10.1007/BF00673149

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