Summary
The amounts of luteinizing hormone (LH) and follicle stimulating hormone (FSH) released in response to the intravenous administration of 12.5, 25, and 100μg of LH-Releasing Hormone (LH-RH) were found to be severely impeded in 4 out of 5 women who had been taking oral contraceptives for periods ranging from 12 to 36 months. Long-term administration of oral contraceptives seems to limit the reserve capacity of the pituitary to release gonadotrophins.
Zusammenfassung
Die Freisetzung von Luteinisierungshormon (LH) und Follikelstimulierungshormon (FSH) nach Injektion von 12,5, 25 und 100μg LH-Releasing Hormone (LH-RH) war bei 4 von 5 Frauen, die 1–3 Jahre lang Ovulationshemmer eingenommen hatten, stark vermindert. Die Fähigkeit der Adenohypophyse zur Freisetzung von Gonadotropinen kann demnach durch eine Langzeitbehandlung mit oralen Antikonzeptiva beeinträchtigt werden.
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Robyn, C., Schöndorf, H., Jürgensen, O. et al. Oral contraception can decrease the pituitary capacity to release gonadotrophins in response to synthetic LH-releasing-hormone. Arch. Gynak. 216, 73–80 (1973). https://doi.org/10.1007/BF00672676
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DOI: https://doi.org/10.1007/BF00672676