International Journal of Theoretical Physics

, Volume 30, Issue 2, pp 129–136 | Cite as

RNA self-splicing and energy localization

  • Ariel Fernández


We establish a mechanism for energy localization in regions of the sugar-phosphate RNA backbone which leads to the formation of transesterification or hydrolysis hot spots. In particular, our results account for the site specificity of the covalent cyclization and cycle reopening in the catalytic intervening sequence (IVS) of a ribosomal RNA.


Hydrolysis Field Theory Elementary Particle Quantum Field Theory Transesterification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bloomfield, V. A., Crothers, D. M., and Tinoco, I. (1974).Physical Chemistry of Nucleic Acids, Harper and Row, New York.Google Scholar
  2. Cantor, C. R., and Schimmel, P. R. (1980).Biophysical Chemistry, Part 1, Chapter 6, Freeman, New York.Google Scholar
  3. Cech, T. R., Zaug, A. J., and Grabowski, P. J. (1981).Cell,27, 487–492.Google Scholar
  4. Fernández, A., (1989a).Naturwissenschaften,76, 469–471.Google Scholar
  5. Fernández, A. (1989b).Chemical Physics Letters,154, 396–402.Google Scholar
  6. Fernández, A. (1991). Coherent collective modes for catalytic RNA,Zeitschrift für Physik B (Condensed Matter).Google Scholar
  7. Marsh, T. L., and Pace, N. R. (1985).Science,229, 79–81.Google Scholar
  8. Peyrard, M., and Bishop, A. R. (1989).Physical Review Letters,62, 2755–2758.Google Scholar
  9. Zaug, A. J., Kent, J. R., and Cech, T. R. (1984).Science,224, 574–578.Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Ariel Fernández
    • 1
    • 2
  1. 1.Department of Biochemistry and Molecular BiologyMedical SchoolMiami
  2. 2.Department of ChemistryUniversity of MiamiCoral Gables

Personalised recommendations