RNA self-splicing and energy localization
- 30 Downloads
We establish a mechanism for energy localization in regions of the sugar-phosphate RNA backbone which leads to the formation of transesterification or hydrolysis hot spots. In particular, our results account for the site specificity of the covalent cyclization and cycle reopening in the catalytic intervening sequence (IVS) of a ribosomal RNA.
KeywordsHydrolysis Field Theory Elementary Particle Quantum Field Theory Transesterification
Unable to display preview. Download preview PDF.
- Bloomfield, V. A., Crothers, D. M., and Tinoco, I. (1974).Physical Chemistry of Nucleic Acids, Harper and Row, New York.Google Scholar
- Cantor, C. R., and Schimmel, P. R. (1980).Biophysical Chemistry, Part 1, Chapter 6, Freeman, New York.Google Scholar
- Cech, T. R., Zaug, A. J., and Grabowski, P. J. (1981).Cell,27, 487–492.Google Scholar
- Fernández, A., (1989a).Naturwissenschaften,76, 469–471.Google Scholar
- Fernández, A. (1989b).Chemical Physics Letters,154, 396–402.Google Scholar
- Fernández, A. (1991). Coherent collective modes for catalytic RNA,Zeitschrift für Physik B (Condensed Matter).Google Scholar
- Marsh, T. L., and Pace, N. R. (1985).Science,229, 79–81.Google Scholar
- Peyrard, M., and Bishop, A. R. (1989).Physical Review Letters,62, 2755–2758.Google Scholar
- Zaug, A. J., Kent, J. R., and Cech, T. R. (1984).Science,224, 574–578.Google Scholar