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Die Plasmareninaktivität in der Schwangerschaft

Plasma renin activity and pregnancy

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Summary

Plasma renin activity (PRA) was determined in 50 normal and 7 hypertonic pregnant women according to the method of Boucher. Statistical evaluation was performed by comparing a control group of 36 nonpregnant women. The results were as following:

  1. 1.

    In normal pregnancy PRA is increased threefold without a concomitant rise in blood pressure.

  2. 2.

    There is no significant change in PRA at the end of pregnancy.

  3. 3.

    The rise of blood pressure in late Toxaemic women is hot concomitant with an elevation of PRA.

The role of renin like substances in the pathogenesis of late toxaemia is discussed. Our results are also discussed with respect to the renin-angiotensin-aldosteron-system and they are compared to the findings of other investigators.

Zusammenfassung

Bei 50 normotonen und 7 hypertonen Schwangeren wurde die Plasmareninaktivität (PRA) mit der Methode nach Boucher bestimmt. Vergleiche mit einem Kontrollkollektiv von 36 Nichtschwangeren führten zu folgenden Ergebnissen:

  1. 1.

    Die PRA ist in der Schwangerschaft etwa um das Dreifache erhöht, ohne daß eine parallele Blutdrucksteigerung feststellbar ist.

  2. 2.

    Zum Ende der Schwangerschaft hin ändert sich die PRA nicht signifikant.

  3. 3.

    Der Hochdruck bei Frauen mit Spätgestose geht nicht mit einer Veränderung des PRA einher. Die Bedeutung reninähnlicher Substanzen für die Pathogenese der Spätgestose wird diskutiert und die Stellung der Befunde im komplizierten Regelkreis des Renin-Angiotensin-Aldosteron-Systems unter Berücksichtigung der Befunde anderer Autoren kritisch diskutiert.

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Authors and Affiliations

  1. Universitäts-Frauenklinik Mainz, Mainz

    A. -W. Schmidt &  J. Rosenthal

  2. I. Medizinische Universitätsklinik Mainz, Mainz

    A. -W. Schmidt &  J. Rosenthal

  3. Dep. of Hypertension, University Hospital, 750 Harrison Avenue, Boston, Mass., USA

    J. Rosenthal

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  1. A. -W. Schmidt
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Mit Unterstützung der Deutschen Forschungsgemeinschaft.

Frau A. Vescei und Fräulein H. Messer danken wir für die zuverlässige technische Mitarbeit.

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Schmidt, A.W., Rosenthal, J. Die Plasmareninaktivität in der Schwangerschaft. Arch. Gynak. 210, 39–48 (1971). https://doi.org/10.1007/BF00668380

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