Summary
Two pregnancy-associated glycoproteins which have been previously described are characterized as reactants of the acute phase: They occur in trace amounts (<0,5 mg per 100 ml) in all or almost all normal sera; elevated levels are found not only during gravidity and hormonal contraception but also in patients suffering from a variety of different diseases. The Ouchterlony gel diffusion technique was used for their detection.
It is proposed to designate the two pregnancy associated glycoproteins asβ 1AP (acute phase)-glycoprotein and α2 AP (acute phase)-glycoprotein. Comparisons are made with C-reactive protein, another acute phase reactant.
The detection of the AP-glycoproteins might prove to be valuable in differential diagnosis as well as in assessing the activity of disease processes and the efficacy of therapy.
Zusammenfassung
Zwei schwangerschafts-assoziierte Glykoproteine werden als „Reaktanten der akuten Phase“ charakterisiert. Sie kommen als Spurenproteine in allen oder fast allen Normalseren vor. In erhöhter Konzentration erscheinen sie im Blut bei Schwangerschaft und oraler Kontrazeption; ihre Konzentration im Serum ist aber, ähnlich wie die des C-reaktiven Proteins, auch bei Patienten mit Tumoren und anderen Erkrankungen vielfach erhöht. Es wird vorgeschlagen, diese schwangerschafts-assoziierten Glykoproteine alsβ 1AP (akute Phase)- und α2AP (akute Phase)-Glykoprotein zu bezeichnen. Der Nachweis dieser Proteine mit der Geldiffusionstechnik nach Ouchterlony und das Vorkommen in Seren von Patienten mit den verschiedensten Erkrankungen wird beschrieben. Vergleiche mit dem C-reaktiven Protein werden angestellt. Eine mögliche Bedeutung der Bestimmung dieser Proteine für differentialdiagnostische Zwecke, zum Nachweis über Ausmaß und Verlauf einer Erkrankung sowie zur Beurteilung der Therapie wird diskutiert.
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Bohn, H. Charakterisierung der schwangerschafts-assoziierten Glykoproteine als akute Phase-Proteine. Arch. Gynäk. 213, 54–72 (1972). https://doi.org/10.1007/BF00668113
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DOI: https://doi.org/10.1007/BF00668113