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Comparison between serum estriol and urinary estrogens as indices of fetoplacental function

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Abstract

In order to compare the predictive efficacies of serum estriol and urinary estrogen excretion in early diagnosis of fetal distress, 255 patients with normal (N=128) or complicated (N=127) pregnancies were monitored with simultaneous determinations of serum estriol (radioimmunoassay) and urinary estrogen excretion/24 h (colorimetric method) after the 32nd week of pregnancy. There was no difference in the efficacies of these tests. Out of all 43 fetal distress cases, 40% were predicted by serum estriol and 33% by urinary estrogens. In pre-eclampsia, the respective findings were 56% and 50%. Fetal distress was the most probable (88%) when both of the tests were low at the same time. In pregnancies complicated with diabetes or rhesus immunization both tests revealed normal findings apart from the presence of fetoplacental dysfunction. The choice between these tests must be based on other factors than the diagnostic accuracy.

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References

  1. Bolognose, R. J., Corson, S. L., Touchstone, J. C.: Factors affecting the yield of urinary estriol. Obstet. Gynecol.39, 683 (1972)

    Google Scholar 

  2. Dieckman, J. W.: The toxemias of pregnancy. Section 1, 2. St. Louis: Mosby 1952.

    Google Scholar 

  3. Dubin, N. H., Crystle, C. D., Grannis, G. F., Townsley, J. D.: Comparison of maternal serum estriol and urinary estrogen determinations as indices of fetal health. Am. J. Obstet. Gynecol.115, 835 (1973)

    Google Scholar 

  4. Fliegner, J. H., Renou, P., Wood, C., Beisher, N. A., Brown, J. B.: Correlation between urinary estriol excretion and foetal acidosis in high-risk pregnancies. Am. J. Obstet. Gynecol.105, 252 (1969)

    Google Scholar 

  5. Frandsen, V., Jorgensen, P. I., Svenstrup, P.: The adventures of one thousands and one obstetrical patients assessed by urinary oestriol excretion. Ann. Clin. Res.2, 354 (1970)

    Google Scholar 

  6. Herrera, L.: The precision of precentiles in establishing normal limits in medicine. J. Lab. Clin. Med.52, 34 (1958)

    Google Scholar 

  7. Lindberg, B. S., Johansson, E. D. B., Nilsson, B. A.: Oestrogens during pregnancy. Acta Obstet. Gynecol. Scand.53 (Suppl.), 32 (1974)

    Google Scholar 

  8. MacLeaod, S. C., Mitton, D. M., Avery, C. R.: Relationship between elevated blood pressure and urinary estriol during pregnancy. Am. J. Obstet. Gynecol.109, 375 (1971)

    Google Scholar 

  9. MacRae, D. J., Mohamedally, S. M.: Comparison between plasma oestriol and urinary oestriol levels in pregnancy. J. Obstet. Gynaecol. Br. Commonw.77, 1088 (1970)

    Google Scholar 

  10. Masson, G. M., Sutherland, H. W.: Plasma oestriol in pregnancy complicated by diabetes mellitus. J. Obstet. Gynecol. Br. Commonw.80, 536 (1973)

    Google Scholar 

  11. Marthur, R. S., Chestnut, S. K., Leaming, A. B., Williamson, H. O.: Application of plasma estriol estimations in the management of high-risk pregnancies. Am. J. Obstet. Gynecol.117, 210 (1973)

    Google Scholar 

  12. Nachtigall, L., Bassett, M., Hogsander, U., Levitz, M.: Plasma estriol levels in normal and abnormal pregnancies: An index of fetal welfare. Am. J. Obstet. Gynecol.101, 638 (1968)

    Google Scholar 

  13. Oakey, R. E., Brandshaw, L. R. A., Eccles, S. S., Stitch, S. R., Heys, R. F.: The rapid estimation of estrogens in pregnancy to monitor foetal risk. Clin. Chim. Acta15, 35 (1967)

    Google Scholar 

  14. Rantakallio, P.: The assessment of small-for-dates infants and associated sociobiological factors. Ann. Chir. Gynaecol. Fenn.62 (Suppl.), 184 (1973)

    Google Scholar 

  15. Schindler, A. E., Keiler, E.: Grundlagen des Steroidstoffwechsels bei Schwangerschaften mit Rh-Inkompatibilität. Z. Geburtsh. Perinat.177, 305 (1973)

    Google Scholar 

  16. Taylor, E. S., Hagerman, D. D., Betz, G., Williams, K. L., Grey, P. A.: Estriol concentration in blood during pregnancy. Am. J. Obstet. Gynecol.108, 868 (1970)

    Google Scholar 

  17. Tulchinsky, D., Abraham, G. E.: Radioimmunoassay of plasma estriol. J. Clin. Endocrinol. Metab.33, 775 (1971)

    Google Scholar 

  18. Ylikorkala, O.: Comparison between urinary oestriol exretion and serum placental lactogen in early detection of intrauterine fetal distress. Aust. N. Z. Obstet. Gynaecol.14, 8 (1975)

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University of Oulu, Oulu

    O. Ylikorkala & P. Jouppila

  2. Isotope Laboratory of Deaconess Institute of Oulu, Oulu, Finland

    J. Haapalahti

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  1. O. Ylikorkala
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  2. J. Haapalahti
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  3. P. Jouppila
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Ylikorkala, O., Haapalahti, J. & Jouppila, P. Comparison between serum estriol and urinary estrogens as indices of fetoplacental function. Arch. Gynäk. 221, 179–185 (1976). https://doi.org/10.1007/BF00667712

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  • DOI: https://doi.org/10.1007/BF00667712

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