Advertisement

Archiv für Gynäkologie

, Volume 221, Issue 1, pp 5–9 | Cite as

Low molecular weight peptides with anti-thrombin and anti-urokinase activity isolated from human maternal and cord blood serum and amniotic fluid

  • Miecyslaw Uszyński
  • Fritz K. Beller
Article
  • 26 Downloads

Summary

Peptides with antithrombin and anti-urokinase activity were isolated from maternal and cord blood serum and amniotic fluid from pregnant women at term. Chromatography data, fingerprinting and activity of peptide inhibitors revealed active peptides, which were similar to those recently isolated from human placenta. They are distinctly different from protein inhibitors previously isolated from human placenta.

Keywords

Public Health Peptide Molecular Weight Pregnant Woman Cord Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Isolierung von Peptiden mit niedrigem Molekulargewicht mit Antithrombin und Antiurokinase aktiviert aus mütterlichem und Nabelschnurserum sowie Fruchtwasser

Zusammenfassung

Peptide mit Antithrombin- und Urokinase-Hemmungsaktivität wurden aus mütterlichem Plasma, Nabelvenenblut und Fruchtwasser isoliert. Chromatographie, “Fingerprints” und die Aktivität von Peptidinhibitoren ergaben aktive Peptide, die ähnlich waren, wie sie von uns kürzlich aus der Plazenta isoliert worden waren. Sie unterscheiden sich wesentlich von Proteininhibitoren, die früher aus Plazenta gewonnen worden sind.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Astrup, T., Seelich, T., Kok, P., Siegel-Balston, A.: Failure to substantiate a low molecular weight inhibitor of fibrinolysis in blood. Nature New Biol.243, 51 (1973)Google Scholar
  2. 2.
    Beller, F. K., Goessner, W., Henschlein, J.: The quantity of tissue activator in the fibrinolytic system of placental tissue. J. Obstetr. Gynec.20, 117 (1962)Google Scholar
  3. 3.
    Brakmann, P., Astrup, T.: In: Thrombosis and Bleeding Disorders (eds. N. N. Bang, F. K. Beller, E. Deutsch, E. F. Mammen), p. 332. Stuttgart and New York: Georg Thieme Verlag/Academic Press 1971Google Scholar
  4. 4.
    Heimburger, N.: Biochemistry of proteinase inhibitors from human plasma: A review of recent developments.Google Scholar
  5. 5.
    Kawano, T., Morimoto, K., Uemura, Y.: Partial purification and properties of urokinase inhibitor. J. Biochem.67, 333 (1970)Google Scholar
  6. 6.
    Kawano, T., Uemura, Y.: Inhibition of tissue activator by urokinase inhibitor. Thrombosis Diath. Haemorrh.25, 129 (1971)Google Scholar
  7. 7.
    Maki, M., Beller, F. K.: Comparative studies of fibrinolytic inhibitors in vitro. Thromb. Haemorrh.26, 668 (1966)Google Scholar
  8. 8.
    Uszyński, M., Uszyński-Folejewska, R.: Plasminogen activator and urokinase inhibitor in myometrium, placenta and amniotic fluid. Amer. J. Obstetr. Gynec.105, 1041 (1969)Google Scholar
  9. 9.
    Uszyński, M., Abildgaard, U.: Separation and characterization of two fibrinolytic inhibitors from human placenta. Thrombosis Diath. Haemorrh.25, 580 (1971)Google Scholar
  10. 10.
    Uszyński, M., Zimmermann, E., Beller, F. K.: The isolation and characterisation of peptides with antiurokinase and antithrombin activity from human placenta. In preparation.Google Scholar
  11. 11.
    Werle, E., Zickgraf-Rudel, G.: Natural proteinase inhibitors distribution, specificity, mode of action and physiological significance. Z. Klin. Chem. u. Klin. Biochem.10, 139 (1972)Google Scholar

Copyright information

© J. F. Bergmann-Verlag 1976

Authors and Affiliations

  • Miecyslaw Uszyński
    • 1
  • Fritz K. Beller
    • 1
  1. 1.Department of Obstetrics and GynecologyWestfälische Wilhelms UniversityMünsterFederal Republic of Germany

Personalised recommendations