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Studies on platelet function during different modes of administration of PgF2α in obstetrics and gynecology

Untersuchungen der Thrombocytenfunktion während unterschiedlichen Applikationsformen von PgF2α in Geburtshilfe und Gynäkologie

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Zusammenfassung

Es wurde die Thrombocytenfunktion bei intravenöser, intraamnialer und extraamnialer Anwendung von PgF2α bei abgestorbener Gravidität, therapeutischem Abort und Geburtseinleitung untersucht. Die Kontrollgruppen erhielten Oxytocin i.v. (abgestorbene Gravidität und Geburtseinleitung). Bei i.v. Anwendung von PgF2α fand sich eine Normalisierung der gesteigerten spontanen Thrombocytenaggregation und eine signifikante Verminderung der ADP- und Kollagen-induzierten Thrombocytenaggregation. Die Desaggregation war in diesen Gruppen verstärkt. Die anderen Gruppen, die PgF2α erhielten, zeigten keine signifikanten Veränderungen der Plättchenfunktion.

Bei Weheninduktion mit Oxytocin war eine Tendenz zu verstärkter Thrombocytenaggregation und verminderter Desaggregation nachzuweisen. Die klinische Bedeutung der gefundenen Veränderungen und die Konsequenzen für die Hämostase werden diskutiert.

Summary

Platelet function has been studied during intravenous, intraamniotic, and extraamniotic administration of prostaglandin F2α (PgF2α) for termination of missed abortion and missed labor, for therapeutic abortion, and for induction of term labor. The controls received oxytocin i.v. (missed labor and term labor). Our investigations have shown that there was a normalization of the increased spontaneous platelet aggregation and a significant reduction of ADP- and collagen-induced platelet aggregation in the groups given PgF2α i.v. The desaggregation in these groups was increased. The other groups given PgF2α showed no significant changes in platelet function.

Inducing labor by oxytocin we found a tendency to increased platelet aggregation and decreased desaggregation. The clinical importance of these findings and the consequences for hemostasis are discussed.

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Authors and Affiliations

  1. Universitäts-Frauenklinik Tübingen, Schleichstraße 4, D-7400, Tübingen, Federal Republic of Germany

    R. C. Briel, E. Kidess, S. Kunz & B. Dieter

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  1. R. C. Briel
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  2. E. Kidess
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  3. S. Kunz
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  4. B. Dieter
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Briel, R.C., Kidess, E., Kunz, S. et al. Studies on platelet function during different modes of administration of PgF2α in obstetrics and gynecology. Arch. Gynak. 225, 201–208 (1978). https://doi.org/10.1007/BF00667202

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  • DOI: https://doi.org/10.1007/BF00667202

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