Relationship between staining by digital subtraction angiography and vascularity in breast cancer: Analysis of the time-density curve and the results of staining for factor VIII-related antigen/von Willebrand factor
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We performed intravenous digital subtraction angiography (IV-DSA) in 31 patients with primary invasive breast cancer, and calculated the maximum density of tumor staining from the time-density curve obtained. Specimens resected from the same patients were stained for factor VIII-related antigen/von Willebrand factor (vWF), and the amount of microvessels was calculated by image processing. A significant correlation (correlation coefficient: 0.85) was found between the maximum density of tumor staining and the vascularity determined by staining for vWF, indicating that the maximum density indirectly reflects the vascularity in the tumor.
Key wordsDSA for breast cancer factor VIII-related antigen/von Willebrand factor angiogenesis vascularity
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