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Formation of dimers in lipid monolayers

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Abstract

In this work, we analyse theoretically the hypothesis that zwitterionic lipids form dimers in adsorption monolayers on water/ hydrocarbon phase boundary. A dimer can be modelled as a couple of lipid molecules whose headgroup lateral dipole moments have antiparallel orientation. Properties including surface pressure, chemical potentials and activity coefficients are deduced from a general expression for the free energy of the monolayer. The theoretical model is in a good agreement with experimental data for surface pressure and surface potential of lipid monolayers. The results favour the hypothesis about formation of dimers in equilibrium with monomers, with the amount of the species depending on the area per molecule and temperature. The reaction of dimerisation turns out to be exothermic with a heat of about 2.5kT per dimer. The results may be applied to the molecular models of membrane structures and mechanisms.

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References

  1. Yue BY, Jackson CM, Taylor JAG, Mingins J, Pethica BA (1976) J Chem Soc Faraday Trans I 72:2685–2693

    Google Scholar 

  2. Taylor JAG, Mingins J, Pethica BA (1976) J Chem Soc Faraday Trans I 72:2694–2702

    Google Scholar 

  3. Pethica BA, Mingins J, Taylor JAG (1976) J Colloid Interface Sci 55:2–8

    Google Scholar 

  4. Mingins J, Taylor JAG, Pethica BA, Jackson CM, Yue BY (1982) J Chem Soc Faraday Trans I 78:323–339

    Google Scholar 

  5. McDonald RC, Simon SA (1987) Proc Natl Acad Sci USA 84:4089–4091

    Google Scholar 

  6. Simon SA, McIntosh TJ, Magid AD (1988) J Colloid Interface Sci 126:74–83

    Google Scholar 

  7. Mingins J, Stigter D, Dill KA (1992) Biophys J 61:1603–1615

    Google Scholar 

  8. Dill KA, Stigter D (1988) Biochemistry 27:3446–3453

    Google Scholar 

  9. Stigter D, Dill KA (1988) Langmuir 4:200–209

    Google Scholar 

  10. Standish MM, Pethica BA (1968) Trans Faraday Soc 64:1113–1122

    Google Scholar 

  11. McIntosh TJ, Magid AD, Simon SA (1987) Biochemistry 26:7325–7332

    Google Scholar 

  12. Simon SA, McIntosh TJ (1989) Proc Natl Acad Sci USA 86:9263–9267

    Google Scholar 

  13. Landau LD, Lifshitz EM (1980) Statistical physics Part I Pergamon Press Oxford

    Google Scholar 

  14. Hill TL (1960) An introduction to statistical thermodynamics. Addison-Wesley Reading, Massachusetts

    Google Scholar 

  15. Heer CV (1972) Statistical mechanics, kinetic theory and stochastic processes Academic Press, London

    Google Scholar 

  16. Prigogine I, Defay R (1954) Chemical thermodynamics Longmans Green, London

    Google Scholar 

  17. Israelachvili JN (1992) Intermolecular and surface forces Academic Press, London

    Google Scholar 

  18. Kauzmann W (1957) Quantum chemistry Academic Press, New York

    Google Scholar 

  19. Press WH, Flannery BP, Tenkolsky SA, Vetterling WT (1987) Numerical recipes: the art of scientific computing. Cambridge University Press, Cambridge

    Google Scholar 

  20. Möhwald H (1990) Annu Rev Phys Chem 41:441–476

    Google Scholar 

  21. Thoma M, Möhwald H (1994) J Colloid Interface Sci 162:340–349

    Google Scholar 

Download references

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Gurkov, T.D., Kralchevsky, P.A. & Nagayama, K. Formation of dimers in lipid monolayers. Colloid Polym Sci 274, 227–238 (1996). https://doi.org/10.1007/BF00665639

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  • DOI: https://doi.org/10.1007/BF00665639

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