Archives of oto-rhino-laryngology

, Volume 217, Issue 2, pp 139–145 | Cite as

The influence of intravenous injection of lidocaine on optokinetic nystagmus in rabbits

  • O. Tokunaga
Article

Summary

The effects of lidocaine in doses of 2.0–6.0 mg/kg with intravenous injection on optokinetic nystagmus were observed in 21 rabbits. No effect of lidocaine was obtained on the frequency of OKN. On the other hand, the amplitude of OKN in lidocaine groups decreased after the injection. The mode and place of the action of lidocaine on OKN were discussed.

Key words

Lidocaine Optokinetic nystagmus 

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References

  1. Bernhard, C. G., Bohm, E.: On the central effects of xylocaine with special reference to its influence on epileptic phenomena. Acta Physiol. Scand.31, Suppl. 114, 5–6 (1954)Google Scholar
  2. Bernhard, C. G., Bohm, E.: The action of local anesthetics on experimental epilepsy in cats and monkeys. Brit. J. Pharmacol.10, 288–295 (1955)Google Scholar
  3. Bochenek, Z., Makowiecka, R.: Behaviour of spontaneous vestibular nystagmus after xylocaine administration. Otolaryng. Pol.23, 151–159 (1969). Excerpta Medica, Section II,23, 173 (1970)Google Scholar
  4. Crawford, O. B.: Comparative qualities of three new local anesthetic drugs: xylocaine, cyclaine, and pravocaine. Anesthesiol.14, 278–290 (1953)Google Scholar
  5. Davidoff, R. A., Atkin, A., Anderson, P. J., Bender, M. B.: Optokinetic nystagmus and cerebral disease. Arch. Neurol. (Chic.)14, 73–81 (1966)Google Scholar
  6. Gejrot, T.: The influence of xylocaine on induced and spontaneous nystagmus. Pract. oto-rhino-laryng.25, 361–366 (1963)Google Scholar
  7. Gardner, R., Weitzman, E. D.: Examination for optokinetic nystagmus in sleep and waking. Arch. Neurol. (Chic.)16, 415–420 (1967)Google Scholar
  8. Ito, I.: Electroencephalographic studies on anticonvulsants. J. Yonago Med. Ass. (Yonago, Japan)9, 644–660 (1958)Google Scholar
  9. Nouri, M. E.: Die Differentialdiagnose des Spontannystagmus. Mschr. Ohrenheilk. (Wien)107, 251–255 (1973)Google Scholar
  10. Sawada, K.: Electroencephalographic studies on mechanisms of adapting to optic stimulation. J. Otolaryng. (Tokyo)71, 777–795 (1968)Google Scholar
  11. Shirabe, S.: Nytagmographische Registrierung des rotatorischen und optokinetischen Nystagmus beim Meerschweinchen und seine Beeinflussung durch Streptomycinsulfat und Dimorpholamin. Arch. klin. exp. Ohr.-, Nas.- u. Kehlk.-Heilk.198, 206–214 (1971)Google Scholar
  12. Tanaka, K., Yasukata, M., Otsubo, Z.: Actions of procaine on the central nervous system of rabbits. Jap. J. Pharmacol.5, 42–47 (1955)Google Scholar
  13. Tibbling, L.: Observations on central mechanisms common to vestibular and optokinetic nystagmus. Acta Otolaryng. (Stockh.)69, 434–442 (1970)Google Scholar
  14. Takakura, T., Mizukoshi, K., Nagaba, M., Ishikawa, K., Honda, H., Ino, H.: On the influence of the several drugs upon the optokinetic nystagmus. Equilibrium Res. (Japan)29, 59–60 (1971)Google Scholar
  15. Waldecker, G.: Über die Wirkung von Phenothiazinen und Dolantin auf den Nystagmus. Arch. Ohr.-, Nas.- u. Kehlk.-Heilk.174, 486–495 (1960)Google Scholar
  16. Yasuda, K.: The effect of intravenous injection of xylocaine on vertigo. Otologia Fukuoka (Fukuoka, Japan)19, 405–410 (1973)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • O. Tokunaga
    • 1
    • 2
  1. 1.Department of Otorhinolaryngology, Faculty of MedicineKyushu UniversityFukuokaJapan
  2. 2.Hals-Nasen-Ohren-Klinik der Medizinischen HochschuleHannoverFederal Republic of Germany

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