Summary
The DNA contents of 29 histologically and ultrastructurally benign pituitary tumours were analyzed with flow-cytofluorometry. — Cytogenetic malignancy, i.e., aneuploidy, was found in 12 cases, independent of endocrinological type of tumour. In 17 cases a diploid DNA content occurred. In aneuploid tumours varying percentage of cells in S-phase was found indicating different growth patterns. Aneuploid DNA pattern was often found in young patients with a short case history. Our findings indicate that analysis of cellular DNA content may reflect the biological properties of pituitary tumours, independent of morphologic characteristics and type of hormone secretion.
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Supported by Grants from the Karolinska Institute, the Ragnar and Torsten Söderberg Foundation (Matti Anniko) and the Cancer Society in Stockholm (Bernhard Tribukait)
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Anniko, M., Holm, L.E., Tribukait, B. et al. Aneuploid DNA pattern in human pituitary adenomas. Arch Otorhinolaryngol 230, 1–4 (1981). https://doi.org/10.1007/BF00665373
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DOI: https://doi.org/10.1007/BF00665373