Pflügers Archiv

, Volume 399, Issue 2, pp 157–159 | Cite as

A hyperpolarization-activated chloride current in xenopus laevis oocytes under voltage-clamp

  • Antonio Peres
  • Giovanni Bernardini
Letters and Notes


Voltage-clamp experiments have been performed on ovulated Xenopus laevis oocytes. Two kinds of oocytes were studied: mature oocytes presenting the white spot due to germinal vesicle breakdown (GVBD) were found to be essentially unexcitable; oocytes without the white spot appeared to possess ionic channels which open transiently on hyperpolarization. The current is carried by chloride ions and, in Holtfreter's solution, has a reversal potential at approximately −15 mV.

Key words

Xenopus laevis ovulated oocytes chloride channels voltage-clamp 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Antonio Peres
    • 1
  • Giovanni Bernardini
    • 1
  1. 1.Dipartimento di Fisiologia e Biochimica GeneraliDipartimento di Biologia dell'Università di MilanoMilanoItaly

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